Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 918-594-3 | CAS number: 7723-14-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1981
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Scientific sound non GLP study similar to Bühler Method with restricted reporting. Sufficient detail available to be able to judge the study as reliable for this end point.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- Deviations:
- yes
- Remarks:
- 10 animals in the treatment group, positive control group only, 10 topical applications
- GLP compliance:
- no
- Remarks:
- performed before GLP guideline
- Type of study:
- Buehler test
Test material
- Reference substance name:
- Phosphorus
- EC Number:
- 231-768-7
- EC Name:
- Phosphorus
- Cas Number:
- 7723-14-0
- IUPAC Name:
- phosphine
- Reference substance name:
- phosphorus
- EC Number:
- 918-594-3
- Cas Number:
- 7723-14-0
- Molecular formula:
- (P)n (Phosphorus red modification)
- IUPAC Name:
- phosphorus
- Details on test material:
- - Name of test material (as cited in study report): oiled red phosphorus Albright and Wilson, LDT. Lot LT 22 RED PHOSPHORUS)
- Substance type: element
- Physical state: solid / powder
- Analytical purity: > 94,6 % +- 1,20 %
- Impurities (identity and concentrations): < 0,0055 % +- 0,0020 % yellow phosphorus
- Composition of test material, percentage of components:approx. 94,6 % total phosphorus, 0,08 % +- 0,010 % mineral oil
Constituent 1
Constituent 2
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- Hartley
- Sex:
- male/female
- Details on test animals and environmental conditions:
- Details on test animals and environmental conditions:
TEST ANIMALS
- Source: charles River Breeding Laboratories, Inc., MA, USA
- Age at study initiation: females: 7weeks males: 9 weeks
- Housing: wired bottom cages
- Diet (e.g. ad libitum): Purina Rat Chow
- Water (e.g. ad libitum): Acified water (pH 2.5)
- Acclimation period: 1 week
ENVIRONMENTAL CONDITIONS
- Temperature (°F): 72° to 76°F
- Humidity (%): 39 to 54 percent relative humidity
- Photoperiod (hrs dark / hrs light): 12h dark / 12h with artificial illumination.
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- epicutaneous, occlusive
- Vehicle:
- physiological saline
- Concentration / amount:
- Study I: intradermal injection 0.1 mL of a 0.1% (w/v) suspension
Study II: concentrations for the patch test range-finding studies were 1.0, 2.0 and 5.0%; 10% in the main study
Challengeopen allclose all
- Route:
- epicutaneous, occlusive
- Vehicle:
- physiological saline
- Concentration / amount:
- Study I: intradermal injection 0.1 mL of a 0.1% (w/v) suspension
Study II: concentrations for the patch test range-finding studies were 1.0, 2.0 and 5.0%; 10% in the main study
- No. of animals per dose:
- 10
- Details on study design:
- The potential of Red Phosphorus to produce skin sensitization was evaluated by two methods
- Study I: Intradermal injections (females)
- Study II: externally applied patches containing the test material (males)
- Study I:
Red Phosphorus was suspended in sterile isotonic saline. 0.1 mL of a 0.1% (w/v) suspension was used for intradermal injection.
- Study II:
The suspensions' concentrations for the Patch test range-finding study were 1, 2 and 5%. In the main study 10% (w/v) suspension was used. All animals used in the patch tests received 0.5 mL of the test material. The positive control was 2,4-Dinitro-1-chlorobenzene, 0.1 mL applied as 0.05% (w/v) solution.
The method included application of the test material or positive control substance to a shaved area of the flank or back 3 times per week for 10 applications. A challenge application was made to a site other than the sensitization site 15 days after the last application. Immediately before each sensitizing application, the reaction from the previous application was evaluated according to the numerical scoring system for skin irritation responses (Draize scoring system). The site of challenge application was evaluated 24 and 48 hours after the challenge. Reaction to the test material at the application site was determined by measurement of the diameter with calipers and estimation of the height and color. The guinea pigs were observed daily for toxic signs.
Topical application for the patch test was accomplished with a dosing band. The band consisted of two 3-inch long strips of 1-inch wide cloth adhesive tape overlapped 0.25 inch. The adhesive side was lined with gauze. A window 2x2 cm square was cut in the band and it was attached to the shaved back of the guinea pig with adhesive tape. The test material was applied to the back of the animal through the dosing window and the window was covered with filter paper. The test substance remained in contact with the skin for 6 hours and was then removed by wiping the area first with cotton soaked in glycerin and then with a gauze pad. In the range-finding study, 2 males per group were treated with 1, 2 or 5% (w/v) suspensions of Red phosphorus once daily for 5 days. Three groups of 10 guinea pigs each were used in the main study. Group 1 received 0.1 mL of a 0.05% (w/v) solution of 2,4-dinitro-1-chlorobenzene in acetone. Group 2 was treated with 10 applications of 0.5 mL 10% (w/v) suspension of Red Phosphorus in sterile saline. Group 3 received 0.5 mL of a 20% Red phosphorus suspension at the challenge application only. - Challenge controls:
- No data
- Positive control substance(s):
- yes
- Remarks:
- 2,4-dinitro-1-chlorobenzene
Results and discussion
- Positive control results:
- Study I:
The positive control guinea pigs' reactions during sensitization were encrustment after 4 to 5 doses. Within 24 hours after challenge doses, the injection sites were hard, red and crusty.
StudyII:
All control animals showed a clear skin reaction after challenge application.
In vivo (non-LLNA)
Resultsopen allclose all
- Reading:
- other: after challenge on study day 35 (study I)
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- 0.1 %
- No. with + reactions:
- 3
- Total no. in group:
- 8
- Clinical observations:
- slight hair loss
- Remarks on result:
- other: Reading: other: after challenge on study day 35 (study I). . Hours after challenge: 24.0. Group: test group. Dose level: 0.1 %. No with. + reactions: 3.0. Total no. in groups: 8.0. Clinical observations: slight hair loss.
- Reading:
- other: 1 st reading (study II)
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- 10%
- No. with + reactions:
- 0
- Total no. in group:
- 10
- Clinical observations:
- no data
- Remarks on result:
- other: Reading: other: 1 st reading (study II). . Hours after challenge: 24.0. Group: test group. Dose level: 10%. No with. + reactions: 0.0. Total no. in groups: 10.0. Clinical observations: no data.
- Reading:
- other: 2 nd reading (study II)
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- 10%
- No. with + reactions:
- 0
- Total no. in group:
- 10
- Clinical observations:
- no data
- Remarks on result:
- other: Reading: other: 2 nd reading (study II). . Hours after challenge: 48.0. Group: test group. Dose level: 10%. No with. + reactions: 0.0. Total no. in groups: 10.0. Clinical observations: no data.
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information
- Conclusions:
- Red Phosphorus showed no sensitizing properties in this study
- Executive summary:
Similar to Buehler Test Red Phosphorus was applied topically 10 times to the skin of guinea pigs at a concentration of 10% (w/w). 15 days after the last application the challenge was conducted and the skin scored according to the Draize scale:
The skin and surrounding hair were stained the same red shade as Red Phosphorus which was not the same color as erythema.There was no response to the challenge dose of Red Phosporus.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.