Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-824-2 | CAS number: 74-95-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted prior to availability of the appropriate OECD and OPPTS testing guidelines. However, the study was well documented and is scientifically acceptable. Hence, it was identified as a key study and was graded klimisch 2.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Guideline is not known
- Principles of method if other than guideline:
- Dibromomethane was applied on surgical gauze and placed directly on the test site of rabbits back. After 24 hours the sheeting and gauze patches
were removed. Observation for signs of dermal irritation or other changes were recorded at 8, 24 and 48 hour intervals after application. - GLP compliance:
- no
Test material
- Reference substance name:
- Dibromomethane
- EC Number:
- 200-824-2
- EC Name:
- Dibromomethane
- Cas Number:
- 74-95-3
- Molecular formula:
- CH2Br2
- IUPAC Name:
- dibromomethane
- Details on test material:
- unspecified purity, DBM. Clear, colourless liquid with a characteristic odour.
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- No further information
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- 0.5 ml of the test material
- Duration of treatment / exposure:
- 24 hours
- Observation period:
- 8, 24 and 48 hour intervals after application
- Number of animals:
- six
- Details on study design:
- Six New Zealand White (NZW) rabbits were closely clipped on the back and sides. The site to the left of the spinal column was abraded, while the site to the right of the spinal column was left intact. 0.5 ml of the test material (unspecified purity, Dibromomethane) was applied on surgical gauze squares 3 cm x and two
layers thick. The gauze was then placed directly on the test site. The animals were then wrapped with plastic sheeting which was secured with adhesive tape to keep the gauze in place. After 24 hours the sheeting and gauze patches were removed. Observation for signs of dermal irritation or other changes were
recorded at 8, 24 and 48 hour intervals after application utilizing the scoring system published in Federal Section 191.11 of the Federal Hazardous Substances Act of the United States. At each observation, all treated sites were scored for erythema (and eschar information), and edema formation.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24h
- Score:
- 2.6
- Max. score:
- 3
- Remarks on result:
- other: moderate to severe
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 48h
- Score:
- 1.33
- Max. score:
- 2
- Remarks on result:
- other: slight, barely perceptible
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24h
- Score:
- 2.1
- Max. score:
- 3
- Remarks on result:
- other: slight, barely perceptible edema with raised edges
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 48h
- Score:
- 0.66
- Max. score:
- 2
- Remarks on result:
- other: scored "none" oedema
- Irritant / corrosive response data:
- Dibromomethane caused moderate to severe skin irritation (erythema and oedema) to NZW rabbits.
Four out of the six rabbits demonstrated well defined to moderate-severe erythema.
None to slight-barely perceptible oedema with raised edges was observed in four out of the six rabbits.
Irritation lasted more than 48 hours following application. Scoring table is attached. - Other effects:
- No further information
Applicant's summary and conclusion
- Conclusions:
- Dibromomethane caused moderate to severe skin irritation (erythema and oedema) to NZW rabbits.
None to slight-barely perceptible oedema with raised edges was observed.
Irritation lasted more than 48 hours following application. - Executive summary:
Dibromomethane caused moderate to severe skin irritation (erythema and oedema) to NZW rabbits. Four out of the six rabbits demonstrated moderate-severe erythema. Two out of the six rabbits demonstrated well defined erythrma. None to slight-barely perceptible edema with raised edges was observed in four out of the six rabbits. Irritation lasted more than 48 hours following application.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.