Registration Dossier
Registration Dossier
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EC number: 260-257-1 | CAS number: 56554-53-1
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Data waiving:
- other justification
- Justification for data waiving:
- other:
- Endpoint:
- hydrolysis
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Validated QSAR model
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
- GLP compliance:
- no
- Estimation method (if used):
- - Total Kb for pH > 8: 8.607 E-002 L/mol sec
- Temperature for which rate constant was calculated: 25 °C
- Computer programme: HYDROWIN v2.00 - pH:
- 7
- Temp.:
- 25 °C
- DT50:
- 2.552 yr
- pH:
- 8
- Temp.:
- 25 °C
- DT50:
- 93.202 d
- Details on results:
- For detailed description on the model and its applicability, see "Any other information on materials and methods incl. tables".
Referenceopen allclose all
Result refers to the uncharged molecule.
Description of key information
Not relevant due to high insolubility in water
Key value for chemical safety assessment
Additional information
No experimental data evaluating the potential for hydrolysis of propane-1,2,3 triyl 3,5,5-trimethylhexanoate (CAS No. 56554-53-1) are available. However, according to Regulation (EC) No. 1907/2006, Annex VIII, column 2, 9.2.2.1, testing for hydrolysis is not required since the substance is highly insoluble in water (water solubility <0.05 mg/L). The results from the supporting QSAR calculations performed with HYDROWIN v2.00 indicate that indeed hydrolysis is not expected to be a relevant degradation pathway for this substance, with estimated half-lives of 2.5 years (pH 7) and 93 days (pH 8)(Müller, 2011).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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