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Diss Factsheets
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EC number: 200-846-2 | CAS number: 75-18-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- sub-chronic toxicity: inhalation
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Secondary literature Documentation insufficient for assessment Original reference not available
Data source
Reference
- Reference Type:
- publication
- Title:
- Dimethyl sulphide
- Author:
- Opdyke DLJ
- Year:
- 1 979
- Bibliographic source:
- Food and Cosmetics Toxicology, 17(4), pp 365-368
Materials and methods
- Principles of method if other than guideline:
- Data not available
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Dimethyl sulphide
- EC Number:
- 200-846-2
- EC Name:
- Dimethyl sulphide
- Cas Number:
- 75-18-3
- Molecular formula:
- C2H6S
- IUPAC Name:
- (methylsulfanyl)methane
- Details on test material:
- Dimethyl sulphide (no other information available)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- data not available
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Vehicle:
- other: no data
- Details on inhalation exposure:
- data not available
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 6 months
- Frequency of treatment:
- 6 h/day
Doses / concentrations
- Remarks:
- Doses / Concentrations:
5 and 25 mg/m3
Basis:
no data
- No. of animals per sex per dose:
- 15 males and 15 females
- Control animals:
- not specified
- Details on study design:
- Post-exposure period: no data
- Positive control:
- data not available
Examinations
- Observations and examinations performed and frequency:
- data not available
- Sacrifice and pathology:
- data not available
- Other examinations:
- data not available
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
25 mg/m3 : Decrease in weight gain, increase in heart
weight, disorders of corticosteroid distribution in the
adrenal tissue, a decrease in oxygen consumption and carbon
dioxide elimination, decreases in catalase activity and the methaemoglobin and phospholipid levels in the blood, and increases in pyruvic acid, lactic acid and thiol groups in whole blood and in tissue homogenates. Increased cholesterol levels in the blood serum.
5 mg/m3 : temporary changes (no detail available)
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.