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Diss Factsheets
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EC number: 200-554-5 | CAS number: 63-05-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Sep to Oct 1994
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 B (Ready Biodegradability: CO2 Evolution Test)
- Deviations:
- no
- GLP compliance:
- yes
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Duration of test (contact time):
- 28 d
- Initial conc.:
- 10 - 20 mg/L
- Based on:
- test mat.
- Reference substance:
- acetic acid, sodium salt
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 60
- Sampling time:
- 9 d
- Parameter:
- % degradation (CO2 evolution)
- Value:
- >= 79 - <= 92
- Sampling time:
- 29 d
- Remarks on result:
- other: 79 % at 20 mg/l; 92 % at 10 mg/l
- Results with reference substance:
- The reference substance passed 60% degradation between day 7 and day 9
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- readily biodegradable
- Conclusions:
- In the study on ready biodegradability a degradation rate of 79 % (20 mg/L) and 92 % (10 mg/L) were determined within 28 days for Androst-4-ene-3,17-dione .
- Executive summary:
The study was conducted in accordance with the OECD Guideline 301 B to assess the ready biodegradability. The test substance was incubated at two concentrations (10 and 20 mg/L) for 28 days. Additionally, a reference substance (sodium acetate) was tested according to the same procedure at a concentration of 20 mg/L. The biological degradation was evaluated by the measurement of the CO2 production. CO2 was determined on days 3, 4, 7, 9, 16, 23 and 29 and the degradation was calculated as the percentage of the theoretical CO2 production based on the structural formula (carbon content). The blank CO2 procution was subtracted for correction. The test compound was degraded to 79 % (20 mg/L) and 92 % (10 mg/L) and therefore has to be classified as "Readily Biodegradable". This study is classified as acceptable and satisfies the guideline requirements for the Ready Biodegradability test.
Reference
Validity criteria for the measurement of the biodegradation according to OECD 301:
Target condition according to guideline: | Actual condition according to the study: | Validity criteria met: |
In order to check the procedure, reference compounds which meet the criteria for ready biodegradability are tested by setting up an appropriate vessel in parallel as part of normal test runs. Suitable compounds are aniline (freshly distilled), sodium acetate and sodium benzoate. | Acetic acid, sodium salt was used as a reference compound. | Yes |
A test is considered valid if the difference of extremes of replicate values of the removal of the test chemical at the plateau, at the end of the test or at the end of the 10-d window, as appropriate, is less than 20% and if the percentage degradation of the reference compound has reached the pass levels by day 14. | % degradation of the test substance at the end of the test (29 d) is 92%
| Yes |
If in a toxicity test, containing both the test substance and a reference compound, less than 35% degradation (based on total DOC) or less than 25% (based on total ThOD or ThCO2) occurred within 14 days, the test substance can be assumed to be inhibitory. The test series should be repeated, using a lower concentration of test substance (if this can be done without seriously impairing the accuracy of the DOC determination) and/or a higher concentration of inoculum, but not greater than 30 mg solids/L. | The used concentrations of the test substance did not show toxic effects to bacteria. | Yes |
Description of key information
In the study on ready biodegradability a degradation rate of 79 % (20 mg/L) and 92 % (10 mg/L) were determined within 29 days for Androst-4-ene-3,17-dione.
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
- Type of water:
- freshwater
Additional information
Androst-4-ene-3,17-dione showed a degradation rate of 79 % (20 mg/L) and 92 % (10 mg/L) within 29 days and therefore has to be classified as "readily biodegradable".
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