Registration Dossier
Registration Dossier
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EC number: 228-845-2 | CAS number: 6362-79-4
Endpoint summary
Administrative data
Description of key information
Additional information
Based on the QSAR methodology of Arnot and Gobas (2003), the subject material is not expected to bioaccumulate in upper trophic level freshwater organisms. In the case of assumed biotransformation, identical estimated BCF and BAF values were obtained for the subject material of 0.8938 L/kg wet-wt. If no biotransformation is assumed, the BCF and BAF values become 0.8972 and 0.8973 L/kg wet-wt, respectively. Based on this QSAR analysis, the subject material has a low potential for bioaccumulation.
Active and passive transport mechanisms might contribute to an increased potential for bioaccumulation (ECHA. Guidance on information requirements and chemical safety assessment. Chapter R.11: PBT Assessment. Appendix R.11 -1. November 2012). Passive transport would be most dependent on the ability to solubilize in and pass through the lipid membrane. For a chemical with a low measured LogPow, such as the subject material, passive diffusion is not expected. Active transport or carrier mediated processes could apply but such processes are generally quite molecule specific and are thus not generally operative. Filtration - or passage of molecules into cells through membrane channels - is generally active or possible only for molecules with molecular weights less than 100 g/Mol. Thus, a weight of evidence conclusion in the case of the current material indicates that it will not readily pass across cellular membranes and is thus of low concern for bioaccumulation.
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