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Diss Factsheets
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EC number: 203-532-3 | CAS number: 107-92-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
In a cell growth inhibition test using cultures of Pseudomonas putida, EC50 and EC10 for butyric acid were determined to be 78 and 51 mg/L respectively.
Key value for chemical safety assessment
- EC50 for microorganisms:
- 78 mg/L
- EC10 or NOEC for microorganisms:
- 51 mg/L
Additional information
The toxicity of butyric acid to microorganisms was tested in six tests. Only two of them are valid. Organisms used are Pseudomonas putida (Hüls, 1996) and Tetrahymena pyriformis (Schultz, 1997). As conservative approach, the study with the lower EC50 is selected as key study (Hüls, 1996).
Hüls 1996, key study
The growth inhibition effect of butyric acid on the bacteria Pseudomonas putida was determined according to the method of Bringmann and Kuehn. Four concentrations ranging from 12 to 100 mg/L were tested in a replicate experiment. Test preparations were incubated at 22°C for 18 hours and bacterial growth was determined measuring the turbidity of the test solution (extinction coefficient at 436 nm).
The EC50 of butyric acid was determined to be 78 mg/L.
The EC10 of butyric acid was determined to be 51 mg/L (Hüls, 1996)
Schultz 1997
In a valid 40 hour growth inhibition study, test cultures of the cilliate Tetrahymena pyriformis were exposed to butyric acid at five graduate concentrations under static conditions (individual concentrations not reported). The assay was performed in three independent replicate runs based on a preceding range finding test.
The EC50 (IGC50) value based on cell density was determined to be 329 mg/L indicating low to moderate toxicity of butyric acid to aqueous microorganisms (cilliates) (Schultz, 2006).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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