Registration Dossier
Registration Dossier
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EC number: 600-736-8 | CAS number: 106276-80-6
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1975
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- Purity not reported
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Fed. Reg. 38 No. 187 §1500.42
- Deviations:
- yes
- Principles of method if other than guideline:
- - Limitations: 3 animals were rinsed after 30 s, 3 animals were not rinsed; Purity not reported
- GLP compliance:
- no
Test material
- Reference substance name:
- 3,3'-(1,4-phenylenediimino)bis[4,5,6,7-tetrachloro-1H-isoindol-1-one]
- EC Number:
- 226-999-5
- EC Name:
- 3,3'-(1,4-phenylenediimino)bis[4,5,6,7-tetrachloro-1H-isoindol-1-one]
- Cas Number:
- 5590-18-1
- Molecular formula:
- C22H6Cl8N4O2
- IUPAC Name:
- 3,3'-(1,4-phenylenediimino)bis(4,5,6,7-tetrachloro-1H-isoindol-1-one)
- Reference substance name:
- mono/bis-methoxy derivatives
- Molecular formula:
- C22-24H6-12Cl6-8N4O2-4
- IUPAC Name:
- mono/bis-methoxy derivatives
- Test material form:
- solid: bulk
Constituent 1
Constituent 2
- Specific details on test material used for the study:
- - Physical state: solid
- Analytical purity: no data
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: Russian
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Housing: separately in V2A wire cages
- Diet (e.g. ad libitum): NAFAG, Gossau SG, CH; ad lib.
- Water (e.g. ad libitum): unspecified; ad lib.
- Acclimation period:
ENVIRONMENTAL CONDITIONS
not reported
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 g - Duration of treatment / exposure:
- 3 animals: without rinsing
3 animals: rinsed after 30 s - Observation period (in vivo):
- 7 days
- Number of animals or in vitro replicates:
- in total 6
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
3 animals: without rinsing
3 animals: rinsed after 30 s
SCORING SYSTEM: OECD Draize Scoring System
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Remarks:
- 6 animals (rinsed or not rinsed)
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- iris score
- Basis:
- mean
- Remarks:
- 6 animals (rinsed or not rinsed)
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Remarks:
- 6 animals (rinsed or not rinsed)
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 3
- Remarks on result:
- no indication of irritation
Any other information on results incl. tables
Criteria for the valuation of chemosis and discharge effects were given in the report, but no detailed results were presented. It is assumed that the parameter "conjunctivae" covers conjunctivae redness and chemosis in combination.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
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