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Diss Factsheets
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EC number: 216-940-1 | CAS number: 1704-62-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: OECD guideline study with acceptable restrictions (no test substance purity given). Acceptable, well documented report which meets basic scientific principles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Version / remarks:
- (adopted 1981)
- Deviations:
- no
- Remarks:
- (no deviations compared to QECD TG 405 , 1981 & 2002, except testing protocol was according to guideline version from 1981)
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-[2-(dimethylamino)ethoxy]ethanol
- EC Number:
- 216-940-1
- EC Name:
- 2-[2-(dimethylamino)ethoxy]ethanol
- Cas Number:
- 1704-62-7
- Molecular formula:
- C6H15NO2
- IUPAC Name:
- 2-[2-(dimethylamino)ethoxy]ethan-1-ol
- Reference substance name:
- DMEE
- IUPAC Name:
- DMEE
- Details on test material:
- - Name of test material (as cited in study report): Lupragen N 107
- Analytical purity: no data
Constituent 1
Constituent 2
Test animals / tissue source
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Gaukler, Offenbach, Germany
- Weight at study initiation: 3.03, 2.54 kg (males); 2.26 kg (female)
- Housing: 1 animal per cage
- Diet: KLIBA 341, 4 mm; Klingentalmuehle AG, CH, ad libitum
- Water: tap water ad libitum
- Acclimation period: at least 1 week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 - 24 °C
- Humidity (%): 30 - 70 %
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated eye of the same animal
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 mL - Duration of treatment / exposure:
- once, eyes were not washed after application
- Observation period (in vivo):
- 15 days
The study was discontinued after 15 days due to severe eye irritation. - Number of animals or in vitro replicates:
- 3 (2 males, 1 female)
- Details on study design:
- APPLICATION
Single application to the conjunctival sac of the right eyelid
REMOVAL OF TEST SUBSTANCE
- Washing (if done): the substance was not washed out
READINGS
1 h, 24 h, 48 h, 72 h, 15 d after application
SCORING SYSTEM: Draize Scoring System
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- other: mean over 24, 48 and 72 h
- Score:
- 1.7
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: Cornea score increased until study termination (3 out of 4).
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Remarks:
- of animal 2 and 3
- Time point:
- other: mean over 24, 48 and 72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: Identical scores in both animals. Cornea score increased until study termination (4 out of 4); staphyloma observed in one animal.
- Irritation parameter:
- iris score
- Basis:
- mean
- Remarks:
- of all 3 animals
- Time point:
- other: mean over 24, 48 and 72 h
- Score:
- 1
- Max. score:
- 2
- Reversibility:
- not reversible
- Remarks on result:
- other: Identical scores in all animals. At study termination: iris score: 1
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Remarks:
- of all 3 animals
- Time point:
- other: mean over 24, 48 and 72 h
- Score:
- 2
- Max. score:
- 3
- Reversibility:
- not reversible
- Remarks on result:
- other: Identical scores in all animals. At study termination: conjunctivae score: 2
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Remarks:
- of animal 1 and 2
- Time point:
- other: mean over 24, 48 and 72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: Identical scores in both animals. At study termination: chemosis score: 2
- Irritation parameter:
- chemosis score
- Basis:
- animal #3
- Time point:
- other: mean over 24, 48 and 72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: At study termination: chemosis score: 1
- Other effects:
- Additional findings observed at study termination (after 15 days):
- animal 1: loss of corneal tissue, small retractions in the eyelids, marginal vascularization of the cornea, pannus, suppuration, loss of hair at margins of eyelids
- animal 2: loss of corneal tissue, small retractions in the eyelids, marginal vascularization of the cornea, pannus, suppuration, staphyloma
- animal 3: loss of corneal tissue, small retractions in the eyelids, pupil contracted, marginal vascularization of the cornea
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
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