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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin sensitisation

Currently viewing:

Administrative data

Endpoint:
skin sensitisation: in vivo (LLNA)
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2003

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
GLP compliance:
yes (incl. QA statement)
Type of study:
mouse local lymph node assay (LLNA)

Test material

Constituent 1
Chemical structure
Reference substance name:
2-bromo-2-methylpropionyl bromide
EC Number:
244-017-3
EC Name:
2-bromo-2-methylpropionyl bromide
Cas Number:
20769-85-1
Molecular formula:
C4H6Br2O
IUPAC Name:
2-bromo-2-methylpropanoyl bromide

In vivo test system

Test animals

Species:
mouse
Strain:
CBA

Study design: in vivo (LLNA)

Vehicle:
acetone/olive oil (4:1 v/v)
Concentration:
2.5, 5 and 10 % v/v
No. of animals per dose:
3 groups of 4 animals

Results and discussion

In vivo (LLNA)

Results
Parameter:
SI
Remarks on result:
other: See the table below

Any other information on results incl. tables

Concentration (% v/v)  Stimulation Index (SI)  Result 
2.5  7.16  Positive 
5  18.58  Positive 
10  23.91  Positive 

Applicant's summary and conclusion

Interpretation of results:
sensitising
Remarks:
Migrated information
Conclusions:
The test material was considered to be a sensitiser under the conditions of the test.