Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 240-004-1 | CAS number: 15875-13-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The material is harmful when applied to the skin and is practically non-toxic when administered orally or in vapor form.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Pre-dates guidelines and GLPs, limited documentation, published in peer reviewed journal
- Principles of method if other than guideline:
- Single oral dose toxicity is estimated by gastric intubation of groups of five non-fasted, Carworth-Wistar male rats, 4-5 weeks of age and weighing 90 to 120 grams. Doses were arranged in logarithmic series differing by a factor of two. Based upon mortalities during a 14-day observation period, the most probable LD50 and its 95% confidence limits are estimated by the method of Thompson and Weil.
- GLP compliance:
- no
- Species:
- rat
- Sex:
- male
- Route of administration:
- oral: gavage
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 3.25 mL/kg bw
- Based on:
- other: 85% aqueous solution
- 95% CL:
- 2.36 - 4.47
- Remarks on result:
- other: Based on a density of 0.912 mg/ml the LD50 would be 2964 mg/kg bw.
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The oral LD50 in male rats of the 85% aqueous solution was 2964 mg/kg bw. The oral LD50 of the active ingredient would be 2519 mg/kg bw
- Executive summary:
The oral LD50 in male rats of the 85% aqueous solution was 2964 mg/kg bw. The oral LD50 of the active ingredient would be 2519 mg/kg bw
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 519 mg/kg bw
- Quality of whole database:
- Studies were done before GLP and Guidelines were established.
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given: study report which meets basic scientific principles, acceptable with restrictions (limited documentation)
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Version / remarks:
- (adopted 1981)
- Deviations:
- yes
- Remarks:
- no analytical verification of test substance concentration
- Principles of method if other than guideline:
- This test (also called inhalation hazard test) was performed in principle as described in OECD Guideline 403. It demonstrates the toxicity of an atmosphere saturated with vapors of the volatile components of a test substance at the temperature chosen for vapor generation (20 °C and 1002.6 hPa).
Several groups of 3 rats per sex were exposed sequentially to the vapors, generated by bubbling 200 l/h air through a substance column of about 5 cm above a fritted glass disc in a glass cylinder containing approximately 120 mL test substance for 8 hours. Compressed air without further filtering was used in order to generate the test substance atmosphere. No analytical determination of the atmosphere concentrations was performed. The nominal concentration was calculated as quotient of the amount of test substance weight loss during the exposure, which was given in the raw data, and the amount of air used during the exposure. Group-wise documentation of clinical signs was performed over the 7-day study period. Body weight of groups was determined before the start of the study and at the end of the observation period in the surviving animals. The clinical signs and findings were reported in summarized form. The study allows for an estimate of the length of time required to cause severe toxic effects resulting from exposure to an atmosphere saturated with volatile components of the test substance. - GLP compliance:
- no
- Test type:
- other: inhalation hazard test
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- - Mean body weight of animals before beginning of exposure:
- males: 177 g (test group 1); 186 g (test group 2);
- females: 173 g (test group 1); 170 g (test group 2). - Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- Inhalation of an atmosphere enriched with vapour at 20°C. For enrichment, 200 L air/h was conducted through a Iayer of about 5 cm of the product.
- Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 8 h
- Concentrations:
- Mean concentration: 0.51 mg/L
- No. of animals per sex per dose:
- 3 animals/sex/dose in one group (two groups are used)
- Control animals:
- yes
- Sex:
- male/female
- Dose descriptor:
- LC0
- Effect level:
- 0.51 mg/L air (nominal)
- Based on:
- test mat.
- Exp. duration:
- 8 h
- Remarks on result:
- other: IHT: No mortality was observed when 12 rats were exposed for 8 hours to an atmosphere that had been saturated at 20°C with the volatile parts of the compound.
- Mortality:
- none
- Clinical signs:
- other: none
- Gross pathology:
- Sacrificed animals: nothing abnormal detected.
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Inhalation EC50 (8-hour) of the substance in rats was determined to be > 0.51 mg/l. No mortality or abnormal clinical signs were observed at this concentration.
- Executive summary:
Inhalation EC50 (8-hour) of the substance in rats was determined to be > 0.51 mg/l. No mortality or abnormal clinical signs were observed at this concentration.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Work pre-dates guidelines and GLPs, Limited documentation, published in peer-reviewed journal
- Principles of method if other than guideline:
- Method: other: no data
- GLP compliance:
- no
- Species:
- rabbit
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 2.02 mL/kg bw
- 95% CL:
- 1.24 - 3.29
- Remarks on result:
- other: Based on a density of 0.912 mg/ml the LD50 would be 1842 mg/kg bw
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The dermal LD50 in rabbits of the 85% aqueous solution is 1842 mg/kg/b.w. The dermal LD50 of the test material is 1566 mg/kg bw.
- Executive summary:
The dermal LD50 in rabbits of the 85% aqueous solution is 1842 mg/kg/b.w. The dermal LD50 of the test material is 1566 mg/kg bw.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 1 566 mg/kg bw
Additional information
Oral LD50 values in rats and mice exceeded 2000 mg/kg bw.
No mortality was observed when rats were exposed for 8 hours to atmospheres that had been saturated with the volatile parts of the compound. No clinical signs or observations after gross pathology were observed. The LC0 was 0.51 mg/L air (nominal).
The acute dermal LD50 in rabbits is 1566 mg/kg bw
Justification for selection of acute toxicity – oral endpoint
Four studies are available one for mice and three for rats. All LD50 values exceed 2000 mg/kg. The rat study with the lowest LD50 value was selected, which represents the most conservative approach.
Justification for selection of acute toxicity – inhalation endpoint
Best documentation of the two available studies
Justification for selection of acute toxicity – dermal endpoint
Only study available
Justification for classification or non-classification
According to the UN Globally Harmonized System of Classification and Labelling of Chemicals (GHS) Part 3 Chapter 3.1 classification is only required for dermal toxicity (cat 4). Data from other routes of exposure do not demonstrate a hazard requiring classification.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.