Registration Dossier
Registration Dossier
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EC number: 205-440-9 | CAS number: 140-90-9
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Justification for type of information:
- This study should not have been performed for animal welfare reasons.
However, it is included as confirmation of severe damage to eyes.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 998
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- not specified
- GLP compliance:
- no
Test material
- Reference substance name:
- Sodium O-ethyl dithiocarbonate
- EC Number:
- 205-440-9
- EC Name:
- Sodium O-ethyl dithiocarbonate
- Cas Number:
- 140-90-9
- Molecular formula:
- C3H6OS2.Na
- IUPAC Name:
- sodium (ethoxymethanethioyl)sulfanide
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- 92.1 wt.% of sodium ethyl xanthate (CAS# 140-90-9)
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- water
- Amount / concentration applied:
- 0.1 ml/eye as water solution
- Observation period (in vivo):
- Observation were made after 1h, 24, 48 hours and then after 7 days
- Number of animals or in vitro replicates:
- 1
- Details on study design:
- was introduced into the conjunctival sacs of the right eye
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 1 h
- Score:
- 33
- Reversibility:
- not fully reversible within: 7 days
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24 h
- Score:
- 33
- Reversibility:
- not fully reversible within: 7 days
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 48 h
- Score:
- 33
- Reversibility:
- not fully reversible within: 7 days
- Irritation parameter:
- other: IIPO
- Basis:
- mean
- Time point:
- other: 7 days
- Score:
- 70
- Reversibility:
- not fully reversible within: 7 days
- Irritant / corrosive response data:
- After 1h no changes were observed in cornea, in iris was noted congestion. Conjunctiva was reddened, red beet color, oedema, and discharge on palpebra. After 24h the observation were the like after 1h. After 48h the changes in eye became more intense. ½ of cornea surface was clouded, pupil was visible in lower part of the eye, details of iris was not visible, the pupil reacted slowly on light. After 7 days changes in the eye became more intense, ¾ of cornea was clouded, in lower part of the cornea details of iris was not visible.IIPO the indicator of acute eye irritation was 33 and after 7 days 70.
Applicant's summary and conclusion
- Interpretation of results:
- corrosive
- Conclusions:
- This study should not have been performed for animal welfare reasons.
However, it is included as confirmation of severe damage to eyes.
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