Registration Dossier
Registration Dossier
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EC number: 401-670-0 | CAS number: 79456-26-1 ACTF; P-007
Long-term toxicity to fish
Administrative data
- Endpoint:
- long-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Not known whether GLP or not
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 987
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 204 (Fish, Prolonged Toxicity Test: 14-day Study)
- Version / remarks:
- 1984
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 3-chloro-5-trifluoromethyl-2-pyridylamine
- EC Number:
- 401-670-0
- EC Name:
- 3-chloro-5-trifluoromethyl-2-pyridylamine
- Cas Number:
- 79456-26-1
- Molecular formula:
- C6H4ClF3N2
- IUPAC Name:
- 3-chloro-5-(trifluoromethyl)pyridin-2-amine
Constituent 1
Sampling and analysis
- Analytical monitoring:
- no
Test organisms
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
Study design
- Test type:
- semi-static
- Total exposure duration:
- 14 d
Test conditions
- Hardness:
- 250 mg CaCO3/l
- Details on test conditions:
- Renewal of test medium three times per week
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 7 d
- Dose descriptor:
- LC50
- Effect conc.:
- 32 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- behaviour
- Duration:
- 14 d
- Dose descriptor:
- LC50
- Effect conc.:
- 27.9 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- behaviour
- Duration:
- 14 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 13 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- behaviour
- Duration:
- 14 d
- Dose descriptor:
- LOEC
- Effect conc.:
- 22 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- behaviour
- Duration:
- 14 d
- Dose descriptor:
- other: LC0
- Effect conc.:
- 17 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- behaviour
- Duration:
- 14 d
- Dose descriptor:
- other: LC100
- Effect conc.:
- 37 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- behaviour
- Details on results:
- Clinical signs appeared after 3 days at dosages >= 17 mg/l.
Mortality appeared on day 2 at 22 mg/l and on day 1 at 27 and 48 mg/l.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
