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EC number: 201-696-0 | CAS number: 86-74-8
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
The maximum steady-state BCF of carbazole were determined to be 241 and 200 at 0.05 and 0.005 mg/L, respectively) (CITI 1992; NITE/CERI 2002/1999).
Key value for chemical safety assessment
- BCF (aquatic species):
- 241
Additional information
Two studies regarding bioaccumulation of carbazole in fish could be identified. One (CITI 1992; NITE/CERI 2002/1999) is a valid study (RL 2) according to accepted principles (flow-through fish test according to OECD TG 305 C).
The other one is a static test system at declining water level during short exposure period without determination of tissue levels (RL3). Kinetic parameters are used for the determination of BCF values (de Voogt et al. 1991). The BCF values determined in the two studies are of the same order of magnitude, though.
NITE/CERI 2002/1999
In a flow-through bioaccumulation test with carp according to OECD TG 305 C over a period of 6 weeks, BCF values of 69 - 241 and of 34 - 200 were determined for test substance concentrations in test medium of 0.05 and 0.005 mg/L, respectively. These results are considered to represent the bioaccumulation potential of carbazole most reliably.
de Voogt et al. 1991
In a static bioaccumulation test with guppies using uptake and depuration rate constants obtained from the aqueous concentration-time course over a period of 48 h, a dynamic BCF of 500 ± 110 (logBCF = 2.7) was determined for carbazole as test substance.
Rate constants were 34.7 ± 4.4 (uptake) and 0.068 ± 0.0012 (depuration) per hour.
Southworth 1979
In a static bioaccumulation test with Daphnia pulex using uptake and depuration rate constants obtained from the concentration-time course of test substance in test solution and in test animals over a 24 h period, a dynamic BCF of 115 ± 3 was determined for carbazole as test substance.
Rate constants were 238 ± 17 (uptake) and 2.06 ± 0.18 (elimination) per hour. Equilibrium conditions were reached after ca. 3 to 4 hours.
In an independent depuration experiment with Daphnia, an elimination rate constant of 0.618 ± 0.064 per hour was determined.
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