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Diss Factsheets
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EC number: 245-846-3 | CAS number: 23727-15-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Endpoint summary
Administrative data
Description of key information
Skin irritation/corrosion:
Irritant to skin (OECD Guideline 404)
Eye irritation/corrosion:
Irritating to eyes (WoE, Kr.2).
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Justification for type of information:
- (-) CAMPHOLENIC ALDEHYDE is an isomer of (+) CAMPHOLENIC ALDEHYDE. Data on (+) CAMPHOLENIC ALDEHYDE can be extrapolated to (-) CAMPHOLENIC ALDEHYDE.
- Reason / purpose for cross-reference:
- read-across source
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24 h
- Score:
- 2
- Max. score:
- 4
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 48 h
- Score:
- 2
- Max. score:
- 4
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 72 h
- Score:
- 1.7
- Max. score:
- 4
- Reversibility:
- fully reversible within: day eight for two animals; very slight erythema seen in one animal at the end of the observation period
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24 h
- Score:
- 3
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 48 h
- Score:
- 2.3
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: day eight for two animals; very slight erythema seen in one animal at the end of the observation period
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 24, 48 and 72 hours
- Score:
- 2
- Max. score:
- 4
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- other: 24, 48 and 72 hours
- Score:
- 2
- Max. score:
- 4
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- other: 24, 48 and 72 hours
- Score:
- 1.7
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: 24, 48 and 72 hours
- Score:
- 3
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- other: 24, 48 and 72 hours
- Score:
- 2.3
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- other: 24, 48 and 72 hours
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 6 days
- Irritant / corrosive response data:
- One hour after patch removal, very slight to well defined erythema (scores 1 and 2) and moderate to severe oedema (scores 3 and 4) were seen in all animals. During the following 72 hours of the test, erythema reactions increased in two animals but decreased in one and oedema reactions decreased in all animals.
The reversibility of these reactions was complete for two animals 6 and 8 days after treatment. The remaining animal still had very slight erythema at the end of the observation period. - Other effects:
- Structural modifications were observed between days 2 and 3; a cutaneous thickening associated with a dryness of the skin in all animals and a slight loss of skin in one animal.
- Interpretation of results:
- irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under the conditions of the test, the test substance was determined to be a skin irritant.
- Executive summary:
In a GLP compliant skin irritation study conducted in line with standardised guideline OECD 404, the skin irritancy of the test substance was determined. Under the conditions of the test, following application of the test substance for four hours under a semi-occlusive patch, very slight to well defined erythema and moderate to severe oedema was seen in all animals. During the following 72 hours, erythema reactions increased in two animals but decreased in one and oedema reactions decreased in all animals. The reversibility of these reactions was complete for two animals 6 and 8 days after treatment and the remaining animal still had very slight erythema at the end of the observation period. The test substance is considered to be a skin irritant.
Reference
Table 1: Individual values of skin reactions
Scores | Mean scores | Scores | |||||
Animal number | 1 hour (D1) | 24 hours | 48 hours | 72 hours | over 24-72h | D5 | D6 |
Erythema | |||||||
7255 | 1 | 2 | 2 | 2 | 2.0 | 2 | 2 |
7270 | 1 | 2 | 2 | 2 | 2.0 | 2 | 1 |
7278 | 2 | 2 | 2 | 1 | 1.7 | 1 | 1 |
Oedema | |||||||
7255 | 4 | 3 | 3 | 3 | 3.0 | 2 | 2 |
7270 | 3 | 3 | 2 | 2 | 2.3 | 2 | 2 |
7278 | 3 | 3 | 2 | 1 | 2.0 | 1 | 0 |
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation, other
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Justification for type of information:
- (-) CAMPHOLENIC ALDEHYDE is an isomer of (+) CAMPHOLENIC ALDEHYDE. Data on (+) CAMPHOLENIC ALDEHYDE can be extrapolated to (-) CAMPHOLENIC ALDEHYDE.
- Reason / purpose for cross-reference:
- read-across source
- Irritation parameter:
- other: Toxtree prediction
- Remarks on result:
- positive indication of irritation
- Other effects / acceptance of results:
- Other effects / acceptance of results
Structural alerts were identified for eye irritation/corrosion for the test substance using Toxtree v3.1.0. - Interpretation of results:
- Category 2 (irritating to eyes) based on GHS criteria
- Conclusions:
- Toxtree evaluation showed alerts for eye irritation/corrosion. Therefore, the test substance is classified into category 2, H319 according to the Regulation (EC) No. 1272/2008.
- Executive summary:
Toxtree v3.1.0 was used to predict the eye irritation/corrosion potential of 2-[(1R)-2,2,3-trimethylcyclopent-3-en-1-yl]acetaldehyde.
The query structure does match structural alerts or examples for eye irritation/corrosion.
Toxtree evaluation showed alerts for eye irritation/corrosion. Therefore, the test substance is considered as irritating to eyes and classified into category 2, H319 according to CLP and UN GHS criteria.
- Endpoint:
- eye irritation, other
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Justification for type of information:
- (-) CAMPHOLENIC ALDEHYDE is an isomer of (+) CAMPHOLENIC ALDEHYDE. Data on (+) CAMPHOLENIC ALDEHYDE can be extrapolated to (-) CAMPHOLENIC ALDEHYDE
- Reason / purpose for cross-reference:
- read-across source
- Irritation parameter:
- other: QSAR result
- Remarks on result:
- no indication of irritation
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- DEREK Nexus evaluation showed no alerts for eye irritation/corrosion.
- Executive summary:
DEREK software ( Derek Nexus: 6.1.0, Nexus: 2.3.0, Lhasa Ltd.) was used to predict the eye irritation/corrosion potential of 2-[(1R)-2,2,3-trimethylcyclopent-3-en-1-yl]acetaldehyde.
The query structure does not match any structural alerts or examples for eye irritation/corrosion in Derek. Additionally, the query structure does not contain any unclassified or misclassified features and is consequently predicted to be non-irritating to eyes.
DEREK Nexus evaluation showed no alerts for eye irritation/corrosion.
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Eye irritation/corrosion:
Two QSARs predictions are available on (+) Campholenic aldehyde (and considered as WoE (Kr.2) are used to determine the classification of (-) Campholenic aldehyde.
1- DEREK software ( Derek Nexus: 6.1.0, Nexus: 2.3.0, Lhasa Ltd.) was used to predict the eye irritation/corrosion potential of 2-[(1R)-2,2,3-trimethylcyclopent-3-en-1-yl]acetaldehyde. The query structure does not match any structural alerts or examples for eye irritation/corrosion in Derek.
Based on the results from the two evaluations, the test substance is considered as irritating to eyes by WoE approach.
Skin irritation/corrosion:
Two GLP compliant studies were performed, one each in accordance with standardised guidelines OECD 404 and EU Method B.4, both with a sufficient level of detail to assess the quality of the presented data. The studies were performed to a good standard and were assigned a reliability score of 1 using the principle for assessing data quality as set out in Klimisch (1997). The key study is the most recently performed study and was slightly better presented. This study concluded that the substance was a skin irritant whereas the supporting study concluded that the substance was not. However, the erythema classification score for the supporting study almost met the criteria for classifying the substance as a skin irritant and so it is considered that the substance should be classified as such.
Justification for classification or non-classification
Harmonised classification:
The substance has no harmonized classification according to the Regulation (EC) No. 1272/2008 and to the GHS.
Self classification:
Eye irritation:
Based on the available data, the test substance is classified as irritant to eyes into category 2, H319 according to the Regulation (EC) No. 1272/2008 (CLP) and the GHS.
Skin irritation:
In line with Directive 67/548/EEC and Regulation 1272/2008, the test substance is considered to be classified as a skin irritant. Under Directive 67/548/EEC the substance has been classified as Xi (Irritant) and R38 (Irritating to skin). Under Regulation 1272/2008, the substance has been classified as Skin Irrit. 2 and H315 (Causes skin irritation).
Respiratory irritation:
No data was available regarding respiratory irritation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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