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EC number: 454-210-6 | CAS number: 13106-24-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
oral: rat, OECD 423, limit test: LD 50 > 2000 mg/kg bw (1/6 animals died at 2000mg/kg bw, possible application error), (BASF, 1998)
inhalation: no data available
dermal: no data available
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- discriminating dose
- Value:
- 2 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
There is one reliable and relevant study available investigating the acute oral toxicity of 1-Butanaminium, N,N-dibutyl-N-methyl-, methyl sulfate.
The study was performed to assess the acute toxicity following oral adininistration of applied a 1-Butanaminum, N,N-dibutyl-N-methyl-, methyl sulfates a solution in aqua bidest., in Wistar rats according to EC and OECD guidelines (OECD 423).
To a group of six fasted animais (three males and three females) a single oral dose of the test material preparation in aqua bidest. at a dose level of 2000 mg/kg body weight was given via gavage. Signs of toxicity were noted in 1 female animal of the 2000 mg/kg dose group comprised poor general state, dyspnoea, abdominal position, atonia and diarrhea.
In all other animals of the 2000 mg/kg dose group (3 males, 2 females) no signs of toxicity were observed. The expected body weight gain was generally observed in the course of the study. 1 female animal of the 2000 mg/kg dose group died 2 hours after application.
Necropsy findings of the animal that died comprised discolouration of all lobes of the lungs, dilatation of the caecum and liquid contents in the caecum. lt can not be excluded that the death was induced by gavage error.
No abnormalities were noted at necropsy of animals sacrificed at the end of the study.
Under the conditions of this study the median lethal dose of 1-Butannminium, N,N-dibutyl-N-methyl-, methyl sulfate after oral application was found to be greater than 2000 mg/kg for the male and female animals (BASF, 1998).
As this study is the only avaiable information, but reliable and good documented, this information is integrated as key study.
Conclusion:
Based on the information received from the acute oral toxicity study the substance is assumed to be practical non toxic as the died animial can be also traced back to a gavage application error. According to the applicant the lung findings suggest a application error, and therefore the substance is rated as not toxic as all other animals did not show any signs of toxicity.
Justification for classification or non-classification
Based on the information 1-Butanaminum, N,N-dibutyl-N-methyl-, methyl sulfates
, a classification is derived according to Regulation (EC) 1272/2008 or Directive 67/548/EEC andthe substance is classified as
- acute oral toxicity: no classification
- acute inhalation toxicity: no data
- acute dermal toxicity: no data
according to Regulation (EC) 1272/2008 or Directive 67/548/EEC.
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