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EC number: 215-290-6 | CAS number: 1319-46-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented publication which meets basic scientific principles
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 983
Materials and methods
- Study type:
- study with volunteers
- Endpoint addressed:
- repeated dose toxicity: oral
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- 22 male police officers exposed to white lead were invited to participate in the investigation: a questionnaire about previous symptoms and diseases, previous occupational status, possible previous and present lead exposure was sent to them and a physical examination was made (blood pressure, estimation of lung function, blood lead concentration)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Trilead bis(carbonate) dihydroxide
- EC Number:
- 215-290-6
- EC Name:
- Trilead bis(carbonate) dihydroxide
- Cas Number:
- 1319-46-6
- Molecular formula:
- C2H2O8Pb3
- IUPAC Name:
- tris(λ²-lead(2+)) dihydroxide dicarbonate
- Details on test material:
- - Name of test material (as cited in study report): white lead
- Substance type: powder
- Physical state: solid
Constituent 1
Method
- Type of population:
- occupational
- Subjects:
- - Number of subjects exposed: 22
- Sex: male
- Age: mean 36 (range 27-68)
- Demographic information: Bureau of Dactylographic Identification in Copenhagen
- Known diseases: none - Ethical approval:
- not specified
- Route of exposure:
- oral
- Reason of exposure:
- unintentional, occupational
- Exposure assessment:
- estimated
- Details on exposure:
- By handling dusts of white lead, the police officers accidentally ingest it
The exposure time varies in a range of 5-30 h/week - Examinations:
- - Haematology: blood pressure, blood lead concentration
- Lung function parameters: yes
Results and discussion
- Clinical signs:
- 1 case of mild lead intoxication: stomach pain, obstipation, ill health
- Results of examinations:
- - Haematology: median blood lead concentration: 0.97 µmol/l (2.75 µmol/l for the case of mild intoxication)
Any other information on results incl. tables
A statistically significant correlation (r = 0.87; p < 0.0001) was found between the blood lead concentrations of the 22 male police officers and the white lead exposure time
Additional data from literature shows that the blood levels encountered in other adult male populations (farmers, workers employed in industry, ...) are around 0.62 -0.68 µmol/l
Applicant's summary and conclusion
- Conclusions:
- The use of white lead among dactylographs can be risky; the study shows that this special kind of lead exposure is relevant.
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