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Diss Factsheets
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EC number: 215-252-9 | CAS number: 1315-01-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- For tin disulfide an algal study is available. This study demonstrated that the tin sulfide has no toxic effects at the limit of water solubility, i.e., at 0.67 µg/L. The other aquatic endpoints were covered using data from tin sulfide which has an almost identical water solubility, i.e., 0.6 µg/L. The algal study was used as bridging study since the WHO concluded in their report that alge are the most sensitive group. Furthermore, the WHO concluded that Sn II is more toxic than Sn IV. Hence, read across from tin sulfide (Sn II) to tin disulfide (Sn IV) was considered justified.
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Duration:
- 3 h
- Dose descriptor:
- other: EC20
- Effect conc.:
- > 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Remarks on result:
- other: 2. Experiment, direct weight
- Results with reference substance (positive control):
- 1. Experiment: EC50 = 12.3 mg/L
2. Experiment: EC50 = 7.3 mg/L - Validity criteria fulfilled:
- yes
- Conclusions:
- In a test on respiration inhibition of activated sludge according to OECD 209, no effects were observed at a nominal concentration of 11 µg/L. In an additional experiment, no effects were observed at concentrations up to 1000 mg/L with directly weighing in.
- Executive summary:
In the test for inhibition of respiration of microorganisms by tin sulfide according to OECD 209 no inhibition has been observed at any concentration, e.g., 11 µg/L and 1000 mg/L. Hence, tin sulfide has no inhibitoriy effect on the microorganisms up to the water solubility.
The results are considered relevant for tin disulfide since both substances have the same metal moiety and have similar physico-chemical properties, e.g., they are almost insoluble in water. Further evidence is provided in the read across justification.
Reference
Percentage of activated sludge respiration inhibition for tested material (1st test):
Concentration [µg/L] |
Inhibition [%] |
11 |
-0.80 |
10 |
-6.63 |
9.1 |
-7.16 |
8.3 |
-7.69 |
7.5 |
-8.22 |
Percentage of activated sludge respiration inhibition for tested material (additional test, directly weighing in):
Concentration [mg/L] |
Inhibition [%] |
1000 |
14.98 |
500 |
9.41 |
250 |
3.14 |
125 |
12.20 |
62.5 |
9.76 |
The results are considered relevant for tin disulfide since both substances have the same metal moiety and have similar physico-chemical properties, e.g., they are almost insoluble in water. Further evidence is provided in the read across justification.
Description of key information
Tin disulfide causes no inhibition of respiration of activated sludge. Determination of EC50 based on the obtained results was not possible. Based on the results obtained during additional test EC50 is above the highest nominal concentration – 1000 mg/L. This suspension was above water solubility level.
Key value for chemical safety assessment
- EC50 for microorganisms:
- 1 000 mg/L
Additional information
The endpoint was covered by read across from tin sulfide.
Tin sulfide, at used concentrations, caused no inhibition of respiration of activated sludge. Determination of EC50 based on the obtained results was not possible. Based on the results obtained during additional test EC50 is above the highest nominal concentration – 1000 mg/L. This suspension was above water solubility level.
Conclusion: Effects from tin sulfide were only observed at concentrations higher than the water solubility of tin sulfide (0.6 µg/L). Therefore, these effects are considered as not relevant. Read across from tin sulfide to tin disulfide was considered as possible (see Read Across justification document attached to the dossier). Hence it can be concluded that there is based on the read across data and the argumentation provided for the read across, there is no risk at the limit of water solubility of tin disulfide, i.e., at 0.67 µg/L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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