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EC number: 237-335-9 | CAS number: 13752-51-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Federal Hazardous Substances Act regulations CFR 16 p.125
- Principles of method if other than guideline:
- Determine the degree of irritation of the eyes of the albino rabbit.
- GLP compliance:
- yes
Test material
- Reference substance name:
- 4-[(morpholinothio)thioxomethyl]morpholine
- EC Number:
- 237-335-9
- EC Name:
- 4-[(morpholinothio)thioxomethyl]morpholine
- Cas Number:
- 13752-51-7
- Molecular formula:
- C9H16N2O2S2
- IUPAC Name:
- morpholin-4-yl morpholine-4-carbodithioate
- Reference substance name:
- Cure-Rite® 18; purity: not noted
- IUPAC Name:
- Cure-Rite® 18; purity: not noted
Constituent 1
Constituent 2
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- The animals were housed and maintained in compliance with the Animal Welfare Act (Pub. L-94-279) 9 CFR part 3.
Temperature: 70 deg F +/- 2 deg F
Relative Humidity: 45% +/- 5%
Light was maintained at 12 hours dark/12 horus light.
Diet: Wayne 15% Rabbit Ration and tap water provided ad libitum.
Caging: stainless steel with elevated wire mesh flooring. 1 rabbit per cage.
Bedding: deotized animal cage board
Each animal was examined with fluorescein dye in order to detect any pre-existing corneal injury.
Test system
- Vehicle:
- not specified
- Amount / concentration applied:
- 0.1g
- Duration of treatment / exposure:
- The dose was applied to the right eye of each animal, the right eye remained untreated to serve as controls.
Exanimation of the treated eyes was done on day 1, 2, 3, 4, and 7 days after application. - Observation period (in vivo):
- 7 days.
- Number of animals or in vitro replicates:
- 9 rabbits.
- Details on study design:
- the first six rabbits did not have their eyes washed subsequent to instillation. the 3 remaining rabbits had the treated eyes washed after 30 seconds for 1 minute with tepid tap water (rate of flow approximately 1000 ml/minute).
Examinations with fluorescein dye were made at the same intervals to confirm the results seen by gross observation. Interpretation of the results was made in accordance with the Draize Scale of Scoring Ocular Lesions.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Remarks:
- all animals
- Time point:
- other: 7 days
- Score:
- 0
- Irritation parameter:
- cornea opacity score
- Time point:
- other: days 1-7
- Score:
- 0
- Max. score:
- 80
- Irritation parameter:
- iris score
- Time point:
- other: days 1-7
- Score:
- 0
- Max. score:
- 10
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Remarks:
- unwashed group (4 affected)
- Time point:
- other: day 1
- Score:
- 3.3
- Max. score:
- 20
- Reversibility:
- fully reversible
- Remarks on result:
- other: no irritation observed by day 2
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Remarks:
- washed group
- Time point:
- other: days 1-7
- Score:
- 0
- Max. score:
- 20
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Remarks on result:
- other: 24/48/72 hour score not specified
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Remarks on result:
- other: 24/48/72 hour score not specified
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Remarks on result:
- other: 24/48/72 hour score not specified
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Remarks on result:
- other: 24/48/72 hour score not specified
- Irritant / corrosive response data:
- 4 out of 6 animals with unwashed treated eyes had a total ocular irritation score between 2 - 8 on day 1, followed by a score of 0 on days 2 - 7.
All 3 animals with washed treated eyes had a total ocular irritation score of 0 on days 1 - 7. - Other effects:
- none
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: other: Federal Hazardous Substances Act Regulations, CFR 16 p125, section 1500.42
- Conclusions:
- The material is not a primary ocular irritant within the definition of the above regulations.
Material is not an ocular irritant in the unwashed or washed eye.
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