Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 431-250-2 | CAS number: 171850-30-9 ODCQA
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Not reported
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: A non-GLP study performed to sound scientific principles with a sufficient level of detail to assess the quality of the submitted data.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
- Report date:
- 1994
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- 0.5 g test substance was administered to intact and abraded skin of two rabbits, one under dry conditions and the other under wet conditions. Five consecutive daily doses of test substance were applied to the intact skin and three consecutive daily applications were made to the abraded site. Each application of test substance was applied under an occlusive dressing, held in place for a 24 hour period. The study was terminated 72 hours after the final dose administration.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 5,7-dichloro-4-hydroxyquinoline-3-carboxylic acid
- EC Number:
- 431-250-2
- EC Name:
- 5,7-dichloro-4-hydroxyquinoline-3-carboxylic acid
- Cas Number:
- 171850-30-9
- Molecular formula:
- C10H5NO3Cl2
- IUPAC Name:
- 5,7-dichloro-4-hydroxyquinoline-3-carboxylic acid
- Details on test material:
- DCHQ-acid
Appearance: white solid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- No further information available on test animals and environmental conditions.
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: intact and abraded
- Vehicle:
- other: unchanged and 0.5% methylcellulose
- Controls:
- no
- Amount / concentration applied:
- 0.5 g neat test substance under dry conditions.
0.5g neat test substance moistened with 0.3 mL of 0.5% methylcellulose for the wet patch application. - Duration of treatment / exposure:
- 5 consecutive daily doses (intact skin)
3 consecutive daily doses (abraded skin) - Observation period:
- 72 hours after the final dose.
- Number of animals:
- 2 (one dosed under dry conditions and one dosed under wet conditions)
- Details on study design:
- The skin irritation test included topical application of 0.5 g of neat test substance to intact and abraded skin on the abdomen of two male New Zealand White rabbits, one under dry conditions and the other under wet conditions. The abdomen of each rabbit was shaved with a straight razor at least three days prior to test initiation. The animals were bandaged for 24 hours after application of the test material to provide occlusion and prevent grooming of the application site. To ensure sufficient contact of test substance with the skin, 0.3 mL of 0.5 % methylcellulose was used to moisten the test substance for the wet patch application.
Twenty four hours after application the bandages were removed and the application sites were graded. Five consecutive daily doses of test substance were applied to the intact skin, and three consecutive daily applications were made to the abraded abdominal site.
The study was terminated 72 hours after the final dose.
Results and discussion
In vivo
- Irritant / corrosive response data:
- Both animals survived the test period. No clinical signs indicative of systemic toxicity were observed. Very slight erythema was observed at the abraded dry patch site after one application and slight exfoliation was observed at the intact wet patch site after three and four doses.
- Other effects:
- No substantial weight change was noted over the duration of the study.
Any other information on results incl. tables
Table 1: Bodyweight in kg
Animal number |
Test day 1 |
Test day 8 |
94A3123 (dry patch) |
3.53 |
3.46 |
94A3138 (wet patch) |
3.58 |
3.47 |
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- Both animals survived the test period. No clinical signs indicative of systemic toxicity were observed. Very slight erythema was observed at the abraded dry patch site after one application and slight exfoliation was observed at the intact wet patch site after three and four doses.
- Executive summary:
Under the conditions of the study, both animals survived the test period. No clinical signs indicative of systemic toxicity were observed. Very slight erythema was observed at the abraded dry patch site after one application and slight exfoliation was observed at the intact wet patch site after three and four doses. Although the reporting of the study does not include scoring of the effects observed the description of these is sufficient to conclude that classification of the substance as a skin irritant is not required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.