3-diethylaminophenol

Acute Toxicity: other routes

Administrative data

Endpoint:

acute toxicity: other routes

Type of information:

experimental study

Adequacy of study:

other information

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: scientifically acceptable and valid study, limited documentation

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1957

Report date:

1957

Materials and methods

Principles of method if other than guideline:

other: BASF-Test (acute intraperitoneal toxicity testing)

GLP compliance:

no

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

3-diethylaminophenol

EC Number:

202-090-9

EC Name:

3-diethylaminophenol

Cas Number:

91-68-9

Molecular formula:

C10H15NO

IUPAC Name:

3-(diethylamino)phenol

Details on test material:

- Name of test material (as cited in study report): Diäthyl-m-aminophenol
- Physical state: solid
- Analytical purity: 99 %
- Other: soluble in acetic acid, alcohol, lutrol, ethylenechloride, unsoluble in soda solution and vegetable oil

Test animals

Species:

mouse

Strain:

not specified

Sex:

male

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: no data
- Age at study initiation: young adult animals were used
- Weight at study initiation: males: 23-34 g

Administration / exposure

Route of administration:

intraperitoneal

Vehicle:

olive oil

Details on exposure:

VEHICLE

- Concentration in vehicle: 10 % and 1 %
- Amount of vehicle: 1-50 ml/kg bw

Doses:

- 50, 100, 200, 400, 500, 5000 mg/kg bw

No. of animals per sex per dose:

50 mg/kg bw: 1 male,
100 mg/kg bw: 5 males,
200 mg/kg bw: 5 males,
400 mg/kg bw: 5 males,
500 mg/kg bw: 1 male,
5000 mg/kg bw: 1 male

Control animals:

no

Details on study design:

- Duration of observation period following administration: no data
- Weighing: body weight was determined before the start of the study only, as it was needed for determination of dose
- Necropsy of survivors performed: no data
- Other examinations performed: clinical signs

Statistics:

- no data

Results and discussion

Effect levels

Sex:

male

Dose descriptor:

LD50

Effect level:

> 100 - < 200 mg/kg bw

Mortality:

50 mg/kg bw: 0/1 male,
100 mg/kg bw: 0/5 males,
200 mg/kg bw: 3/5 males within 1-3 days,
400 mg/kg bw: 5/5 males within 1 hour,
500 mg/kg bw: 1/1 male within 11 minutes,
5000 mg/kg bw: 1/1 male within 5 minutes,

Clinical signs:

Death occured after symptoms like dyspnea, tremor and hypotonia. The animals tendend to lateral position or were like narcotized. Some of them showed excessive lacrimation and salivation.

Symptoms anmong animals which received middle doses were changes in depth and rate of breathing, apathy, strong ataxia, scrubby and grubby fur, loss of appetite and diarrhea.

The same symptoms were observed in the low dose groups, except diarrhea.
After 5 days these symptoms disappeared.

Body weight:

- no data

Gross pathology:

- no data