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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 204-436-4 | CAS number: 120-93-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Rat Hepatic Microsomal Metabolism of Ethylenethiourea. Contributions of the Flavin-Containing Monooxygenase and Cytochrome P-450 Isozymes.
- Author:
- Decker C.J. et al.
- Year:
- 1 991
- Bibliographic source:
- Chem. Res. Toxicol. 4, 482-489
Materials and methods
- Objective of study:
- metabolism
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Microsomes were incubated with ethylenethiourea (ETU) or 2-imidazolidone (EU) ± NADPH and then recovered by centrifugation for the determination of P-450 enzymatic activity.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2-imidazolidone
- EC Number:
- 204-436-4
- EC Name:
- 2-imidazolidone
- Cas Number:
- 120-93-4
- Molecular formula:
- C3H6N2O
- IUPAC Name:
- 2-imidazolidone
- Test material form:
- solid
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Simonsen Labs, Gilroy, CA
- Weight: 220-250 g
ENVIRONMENTAL CONDITIONS
No data
IN-LIFE DATES: No data
Administration / exposure
- Route of administration:
- other: not specified
- Vehicle:
- not specified
- Details on exposure:
- Sprague-Dawley rats were administered PB (phenobarbital), DEX (dexamethasone), or BNF (ß-naphthoflavone) and liver microsomes were prepared. Protein concentrations were determined by the method of Lowry et al (1951).
- Duration and frequency of treatment / exposure:
- no data
Doses / concentrations
- Remarks:
- No data
- No. of animals per sex per dose / concentration:
- no data
- Control animals:
- not specified
- Positive control reference chemical:
- no data
- Details on study design:
- Biochemical Assays. Microsomal incubations (6.0 mL) contained 1.0 or 2.0 mM ETU or EU, 1-2 mg/mL microsomal protein, 1.5 mM DTPC, and in some cases 1.0 mM NADPH, 5.0 mM GSH, 0.1 mg/mL superoxide dismutase, or 0.5 mg/mL catalase in 0.1 M phosphate buffer, pH 7.4. Reactions were initiated by the addition of NADPH (+NADPH) or buffer (- NADPH) and were incubated at 37 °C for 15 min. For the heat inactivation studies, microsomes were incubated at 37 °C (in the absence of NADPH) for 1 h prior to incubation with ETU.
Results and discussion
Main ADME results
- Type:
- metabolism
- Results:
- Under normal physiological conditions, reactive metabolites from EU generated by either flavin-containning monooxygenase (FMO) or cytochrom P-450 are preferentially trapped by endogenous GSH and do not interact with cellular targets.
Metabolite characterisation studies
- Details on metabolites:
- Under normal physiological conditions, reactive metabolites from EU generated by either FMO or P-450 are preferentially trapped by endogenous GSH and do not interact with cellular targets.
Any other information on results incl. tables
Under normal physiological conditions, reactive metabolites from EU generated by either FMO or P-450 are preferentially trapped by endogenous GSH and do not interact with cellular targets.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.