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EC number: 206-200-6 | CAS number: 307-35-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Developmental toxicity / teratogenicity
Administrative data
- Endpoint:
- developmental toxicity
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The experimental study is referred to PFOS (Potassium Perfluorooctane sulfonic acid). The substance RM90 is a salt of PFOS.
Data source
Reference
- Reference Type:
- publication
- Title:
- ENVIRONMENTAL AND HEALTH ASSESSMENT OF PERFLUOROOCTANE SULFONIC ACID AND ITS SALTS
- Author:
- 3M
- Bibliographic source:
- Various sources listed in the assessment report.
- Report date:
- 2003
Materials and methods
Test guideline
- Guideline:
- other: not known
- Principles of method if other than guideline:
- Method not available in the pubblication.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Heptadecafluorooctane-1-sulphonic acid
- EC Number:
- 217-179-8
- EC Name:
- Heptadecafluorooctane-1-sulphonic acid
- Cas Number:
- 1763-23-1
- IUPAC Name:
- 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluorooctane-1-sulfonic acid
Constituent 1
Test animals
- Species:
- other: rats and rabbits
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- Pregnant rats and rabbits on prenatal development of their embryos and fetuses.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Analytical verification of doses or concentrations:
- not specified
Results and discussion
Results (fetuses)
- Details on embryotoxic / teratogenic effects:
- Embryotoxic / teratogenic effects:yes
Details on embryotoxic / teratogenic effects:
PFOS caused maternal and fetal toxicity. Initial studies with PFOS reported a lesion in the lens of the eye in all treated groups. The study director subsequently retracted the causal association between this effect and chemical exposurwhen it was established that the “lesion” was an artifact associated with the method of free-hansectioning used in the fetal examination. These lesions were not observed in a repeat study in same laboratory that conducted the original study.
Since those original studies were conducted, additional prenatal developmental toxicity studiehave been performed in the rat and rabbit (Case et al., 2001a).
Results in the three PFOS studies were similar. Maternal toxicity and developmental toxicity were expressed as reductions in maternal weight gain or fetal body weight. Reductions in food consumption commonly paralleled the effect on maternal weight. Fetal effects were primarily associated with maturational delays, e.g., skeletal variations and delayed ossification. Abortions were observed in rabbits at a dose of 2.5 mg/kg and higher. The lowest developmental toxicity NOAEL for rat and rabbit were the same, 1 mg/kg body weight. The maternal toxicity NOAEL was 0.1 and 1.0 mg/kg for rabbit and rat, respectively. Fetal toxicity, rather than anatomical malformations, characterized the principal effectof PFOS. Developmental effects were seen only in conjunction with maternal toxicity, indicating that PFOS is not a selective developmental toxicant.
In a recent study, findings of cleft palate, anasarca, ventricular septal defect, and enlargement of the right atrium were found in rat and mouse fetuses, primarily at maternal doses of 10 and 20 mg/kg/day, respectively (Thibodeaux et al., 2003). In these studies, pregnant rats were given doses of 1,2, 3, 5,or 10 mg/k ay from gestational day (GD) 2 through GD 20, and pregnant CD-1 mice were given 1, 5, 10, 15, and 20mg/kg/day from GD 1 through GD 17. Maternal weight gains and serum triglycerides were reduced in a dose-dependent manner in both species, and pregnant mice experienced marked liver enlargement at 10, 15, and 20 mg/kg/day dose levels. The numbers of implantation sites and live fetuses at birth were not altered as compared to controls; however, fetal weight in the rats was slightly reduced. The birth defects that occurred were at doses that produced significant maternal toxicity.
Fetal abnormalities
- Abnormalities:
- not specified
Overall developmental toxicity
- Developmental effects observed:
- not specified
Any other information on results incl. tables
Design | NOAEL (mg/kg) | LOAEL (mg/kg) | Effects |
Rat SD, Group size: 22;Dose (a): 0, 1, 5, 10 | Maternal 5; Development 10 | Maternal 10; Development none | Maternal Body weight |
Rat SD; Group size: 25; Dose (a): 0, 1, 5, 10 | Maternal 1; Development 1 | Maternal 5; Development 5 | Maternal Body weight; Clinical signs g.i. lesions. Dev. Body wt, visc, anom, skel. var. |
Rabbit NZW; Group size: 22; Dose (a): 0,0.1, 1, 2.5, 3.75 | Maternal 0.1; Development 1 | Maternal1; Development 2.5 | Maternal body weight, abortionsDev. Body wt., delayed ossification |
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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