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Diss Factsheets
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EC number: 248-433-6 | CAS number: 27375-52-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- no
- Species:
- human
- Type of coverage:
- other: semiocclusive and occlusive
- Preparation of test site:
- not specified
- Vehicle:
- not specified
- Controls:
- not specified
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Score:
- 0.926
- Reversibility:
- no data
- Remarks on result:
- other: not irritating to the skin of human
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- By primary dermal irritation index (PDII) from QSAR , skin irritation score of N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide estimated as 0.926 based on this score it is indicated that N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide is not irritating to the skin of human.
- Executive summary:
By primary dermal irritation index (PDII) from QSAR , skin irritation score of N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide estimated as 0.926 based on this score it is indicated that N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide is not irritating to the skin of human.
Reference
The prediction was based on dataset comprised from the following descriptors: "Primary Irritation Index"
Estimation method: Taking average value from the 5 nearest neighbours
Domain logical expression:Result: In Domain
(("a" and "b" ) and ("c" and "d" ) )
Domain logical expression index: "a"
Similarity boundary:Target: c1(S(=O)(=O)CCO)ccc(NC(C)=O)cc1
Threshold=50%,
Dice(Atom pairs)
Domain logical expression index: "b"
Similarity boundary:Target: c1(S(=O)(=O)CCO)ccc(NC(C)=O)cc1
Threshold=60%,
Dice(Atom pairs)
Domain logical expression index: "c"
Parametric boundary:The target chemical should have a value of log Kow which is >= -1.54
Domain logical expression index: "d"
Parametric boundary:The target chemical should have a value of log Kow which is <= 0.735
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
- Qualifier:
- according to guideline
- Guideline:
- other: Estimated data
- Principles of method if other than guideline:
- Prediction is done using QSAR Toolbox version 2.3.
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- not specified
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- 1-30 percent
- Duration of treatment / exposure:
- 1-3 days
- Number of animals or in vitro replicates:
- 3-6
- Irritation parameter:
- other: MMAS(modified maximum average score (MMAS))
- Basis:
- mean
- Score:
- 22.2
- Reversibility:
- not specified
- Remarks on result:
- other: not irritating to eye
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The modified maximum average score (MMAS) from QSAR eye irritation score of N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide is estimated as 22.2. This score indicates that N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide is not irritating to the eye of rabbit.(as the criteria MMAS <25 is not irritating).
- Executive summary:
The modified maximum average score (MMAS) from QSAR eye irritation score of N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide is estimated as 22.2. This score indicates that N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide is not irritating to the eye of rabbit.(as the criteria MMAS <25 is not irritating).
Reference
The prediction was based on dataset comprised from the following descriptors: MMAS
Estimation method: Taking average value from the 5 nearest neighbours
Domain logical expression:Result: In Domain
("a" and ("b" and "c" ) )
Domain logical expression index: "a"
Similarity boundary:Target: c1(S(=O)(=O)CCO)ccc(NC(C)=O)cc1
Threshold=50%,
Dice(Atom pairs)
Domain logical expression index: "b"
Parametric boundary:The target chemical should have a value of log Kow which is >= -0.843
Domain logical expression index: "c"
Parametric boundary:The target chemical should have a value of log Kow which is <= 1.53
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation
By primary dermal irritation index (PDII) from QSAR , skin irritation score of N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide estimated as 0.926 based on this score it is indicated that N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide is not irritating to the skin of human.
Eye irritation
The modified maximum average score (MMAS) from QSAR eye irritation score of N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide is estimated as 22.2. This score indicates that N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide is not irritating to the eye of rabbit.(as the criteria MMAS <25 is not irritating).
Justification for selection of skin irritation / corrosion endpoint:
By primary dermal irritation index (PDII) from QSAR , skin irritation score of N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide estimated as 0.926 based on this score it is indicated that N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide is not irritating to the skin of human.
Justification for selection of eye irritation endpoint:
The modified maximum average score (MMAS) from QSAR eye irritation score of N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide is estimated as 22.2. This score indicates that N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide is not irritating to the eye of rabbit.(as the criteria MMAS <25 is not irritating).
Justification for classification or non-classification
The available studies indicate that N-[4-[(2-hydroxyethyl) sulphonyl]phenyl] acetamide is not classified as a skin and eye irritant, according to CLP regulation.
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