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Diss Factsheets
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EC number: 206-190-3 | CAS number: 306-83-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1975
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study scientifically acceptable. No GLP compliant, not in line with OECD TG
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Appears to be similar to OECD Guidelines for skin sensitization (406), however, limited methodology was provided to completely assess similarity to OECD guidelines. No information was provided on positive control to assess validity of study.
- GLP compliance:
- no
- Type of study:
- guinea pig maximisation test
- Justification for non-LLNA method:
- At the time of testing (1975), the LLNA method was not yet adopted as OECD Guideline and not yet identified as the standard information requirement. For this reason the use of the guinea pig maximisation test (GPMT) was considered to be acceptable.
Test material
- Reference substance name:
- 2,2-dichloro-1,1,1-trifluoroethane
- EC Number:
- 206-190-3
- EC Name:
- 2,2-dichloro-1,1,1-trifluoroethane
- Cas Number:
- 306-83-2
- Molecular formula:
- C2HCl2F3
- IUPAC Name:
- 2,2-dichloro-1,1,1-trifluoroethane
- Reference substance name:
- Ethane, 2,2-dichloro-1,1,1-trifluoro- -
- IUPAC Name:
- Ethane, 2,2-dichloro-1,1,1-trifluoro- -
- Details on test material:
- - Name of test material (as cited in study report): Ethane, 1,1-Dichloro-2,2,2-Trifluoro (FC-123)
- Molecular formula (if other than submission substance): CHCL2CF3
- Molecular weight (if other than submission substance): 153 g/mole
- Physical state: liquid
- Purity: 99.9405% FC-123
Constituent 1
Constituent 2
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- other: Species not specified, male albino
- Sex:
- male
- Details on test animals and environmental conditions:
- TEST ANIMALS
Initial average body weight = 580 g
Final average body weight = 779 g
Control animals average body weight = 740 g
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- intradermal
- Vehicle:
- other: Intradermal injection included dimethyl phthalate and the challange agent included propylene glycol
- Concentration / amount:
- Intradermal injections consisted of 1% solution (vol./vol.) of test material in dimethyl phthalate (DMP). The challenge solution was 50% and a 10% solution (wt./vol.) of test material in propylene glycol.
Challengeopen allclose all
- Route:
- epicutaneous, occlusive
- Vehicle:
- other: Intradermal injection included dimethyl phthalate and the challange agent included propylene glycol
- Concentration / amount:
- Intradermal injections consisted of 1% solution (vol./vol.) of test material in dimethyl phthalate (DMP). The challenge solution was 50% and a 10% solution (wt./vol.) of test material in propylene glycol.
- No. of animals per dose:
- 10 animals per dose
- Details on study design:
- MAIN STUDY
A. INDUCTION EXPOSURE
- No. of exposures: 4 sacral intradermal injections
- Exposure period: 3-week period
- Test groups: 10 animals per dose
- Control group: 10 animals
- Frequency of applications: One injection per week
- Concentrations: 0.1 mL of a 1% solution (vol/vol) of test material in dimethyl phthalate (DMP)
- Rest period prior to challenge: Two weeks
B. CHALLENGE EXPOSURE
- Test groups: 10 animals per dose group
- Control group: 10 animals per dose group
- Site: Shoulder
- Concentrations: 50% and 10% - 1 drop (~0.05 mL) each of a 50% and a 10% solution (wt/vol) of test material in propylene glycol was lightly rubbed on the shaved intact shoulder skin.
- Evaluation (hour after challenge): 24 hours and 48 hours
- Challenge controls:
- 10 previously unexposed guinea pigs received similar applications at the time of challenge to provide a direct comparison of the challenge reactions on skin of similar age.
- Positive control substance(s):
- not specified
Results and discussion
In vivo (non-LLNA)
Resultsopen allclose all
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- 50%
- No. with + reactions:
- 0
- Total no. in group:
- 10
- Remarks on result:
- other: Reading: 1st reading. . Hours after challenge: 24.0. Group: test group. Dose level: 50%. No with. + reactions: 0.0. Total no. in groups: 10.0.
- Reading:
- 2nd reading
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- 50%
- No. with + reactions:
- 0
- Total no. in group:
- 10
- Remarks on result:
- other: Reading: 2nd reading. . Hours after challenge: 48.0. Group: test group. Dose level: 50%. No with. + reactions: 0.0. Total no. in groups: 10.0.
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- 10%
- No. with + reactions:
- 0
- Total no. in group:
- 10
- Remarks on result:
- other: Reading: 1st reading. . Hours after challenge: 24.0. Group: test group. Dose level: 10%. No with. + reactions: 0.0. Total no. in groups: 10.0.
- Reading:
- 2nd reading
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- 10%
- No. with + reactions:
- 0
- Total no. in group:
- 10
- Remarks on result:
- other: Reading: 2nd reading. . Hours after challenge: 48.0. Group: test group. Dose level: 10%. No with. + reactions: 0.0. Total no. in groups: 10.0.
Applicant's summary and conclusion
- Conclusions:
- Under the conditions of this study, no sensitization was observed at challenge in a guinea pig skin sensitization test with 1,1,-dichloro-2,2,2-trifluoro-ethane in a 50% and a 10% solution in propylene glycol.
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