Cinnamyl alcohol

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Justification for type of information:

Experimental test result performed using standard OECD test guidelines.

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

GLP compliance:

no

Type of method:

other: Spectrophotometric analytical method

Key result

Water solubility:

2 542.3 mg/L

Conc. based on:

test mat.

Temp.:

25 °C

Remarks on result:

other: Soluble in water

WATER SOLUBILITY: CONFIRMATORY TEST

Five times the concentration recorded from preliminary solubility = 810.64 mg/L × 5 = 4053.2 mg/L was used for confirmatory

study. Two separate solution of 405.32 mg in 100 ml DI water were prepared and kept for stirring for 48 hrs and 72 hrs. After

the completion of stirring period the absorbance for all the two solution were recorded and concentration was detected on the

basis of standard curve. Table 2 refers to the same.

Sample stirring	Concentration obtained on the basis of standard curve	Dilution factor	Solubility value obtained (mg/L)
24 hour	-	-	-
48 hour	6.6667 mg/L	400	2666.68 mg/L
72 hour	6.0448 mg/L	400	2417.92 mg/L

Considering the water solubility for 48 hrs and 72 hrs the mean water solubility was calculated as follows:

Mean water solubility value for 48 hour run sample + 72 hour run sample

=(2666.68+2417.92)/2

=2542.3 mg/L

Conclusions:

The water solubility of the test chemical was determined to be 2542.3 mg/L at 25°C.

Executive summary:

The water solubility determination of test chemical was done as per the OECD guideline 105 by spectrophotometric analytical method as per OECD 101. The solubility of of test chemical in water was determined to be 2542.3 mg/L at 25°C.

Description of key information

The water solubility determination of test chemical was done as per the OECD guideline 105 by spectrophotometric analytical method as per OECD 101. The solubility of of test chemical in water was determined to be 2542.3 mg/L at 25°C.

Key value for chemical safety assessment

Water solubility:

2 542.3 mg/L

at the temperature of:

25 °C

Additional information

The water solubility determination of test chemical was done as per the OECD guideline 105 by spectrophotometric analytical method as per OECD 101. The solubility of of test chemical in water was determined to be 2542.3 mg/L at 25°C.

Based on available experimental report the solubility of Cinnamyl alcohol  in water was detrmined by Shake flask method, and was determined to be 10000 mg/l at temperature of 27 deg C.

Other supporting data from authoritative and modelling databases, also supported the selected key study and exhibited the solubilty of

Cinnamyl alcohol at 25 deg C as 6188 mg/l.

Based on the experimental and estimated value, the test substance Cinnamyl alcohol was considered to be soluble in water.