Registration Dossier
Registration Dossier
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EC number: 210-361-8 | CAS number: 613-92-3
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation / corrosion
- Remarks:
- other: In silico prediction.
- Type of information:
- (Q)SAR
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Study period:
- May, 2010
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Prediction with low reliability index from the software Tox Boxes 2.9.
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Skin irritation module estimates the potential of a compound to cause skin irritation in a standard rabbit Draize test.
Tox Boxes 2.9 is the in house software for the prediction of basic toxicity endpoints in chemicals. Predictions are made analyzing the chemical structure and based upon large validated databases and QSAR models, in combination with expert knowledge of organic chemistry and toxicology. - GLP compliance:
- not specified
Test material
- Reference substance name:
- Benzamide oxime
- EC Number:
- 210-361-8
- EC Name:
- Benzamide oxime
- Cas Number:
- 613-92-3
- Molecular formula:
- C7H8N2O
- IUPAC Name:
- N-hydroxybenzenecarboximidamide
Constituent 1
Test animals
- Strain:
- not specified
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- not specified
- Number of animals:
- No animals used.
Results and discussion
In vivo
Results
- Remarks on result:
- other: Shows moderate irritation value with low reliablity index
Applicant's summary and conclusion
- Interpretation of results:
- other: moderate alert
- Remarks:
- Criteria used for interpretation of results: expert judgment
- Conclusions:
- Skin irritation overview indicates a moderate alert with low reliability index.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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