Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-552-2 | CAS number: 108-12-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Parent compound isovaleryl chloride: No data available.
Hydrolysis product isovaleric acid: No data available.
There are no experimental data available for the parent compound and its hydrolysis product, therefore the short-term toxicity to fish is assessed on the results of the structurally similar substance valeryl chloride and its hydrolysis product valeric acid.
Valeryl chloride: With high probability acutely not harmful to fish (after pH-adjustment).
Valeric acid: Acutely harmful to fish.
Hydrolysis product HCl: Acutely toxic for fish (pH-dependent).
Key value for chemical safety assessment
Additional information
Isovaleryl chloride (CAS 108-12-3) rapidly decomposes in water and forms HCl (CAS 7647-01-0) and isovaleric acid (CAS 503-74-2). Since there are neither experimental data available for isovaleryl chloride nor for its hydrolysis product isovaleric acid, short-term toxicity to fish is assessed via read across to the structurally similar substances isobutyryl chloride (CAS 79-30-1), isobutyric acid (CAS 79-31-2), valeryl chloride (CAS 638-29-9) and valeric acid (CAS 109-52-4).
Isobutyryl chloride and isobutyric acid:
The toxicity of isobutyryl chloride to the test organism Danio rerio was tested according to OECD 203 (Fish, acute Toxicity Test). The 96-h LC50 was determined to be 280.7 mg/L (measured, not neutralized; BASF, 1999; report no. 17F0505/965151).
The toxicity of isobutyric acid to Leuciscus idus was tested according to German Industrial Standard DIN 38412, part 15. No analytical monitoring was performed. The 96-h LC50 was determined to be 146.6 mg/L (nominal; not neutralised; BASF, 1989; report no. 10F0167/89107).
Valeryl chloride and valeric acid:
The acute fish toxicity of valeryl chloride (638 -29 -9) was determined withLeuciscus idusaccording to the German Industrial Standard DIN 38412, L15. The obtainedLC50 (96 h) was 68.1 mg/L. When tested under neutralised conditions (pH-adjustment), the LC50 was > 100 mg/L (BASF, 1987;report no.10F0207/875168).
The acute fish toxicity of valeric acid (CAS 109 -52 -4) to the test organism Pimephales promelas was studied in two acute toxicity tests according to guidelines of the American Public Health Association, 1971 (Standard methods for the Examination of Water and Wastewater). The obtained 96 -h LC50 values were 77 mg/L and 39 mg/L, respectively (geometric mean LC50 = 54.8 mg/L; Mattson et al. 1976; ECHA, 2011).
Based on the available data, isovaleryl chloride is assessed to be with high probability acutely not harmful to fish (after pH-adjustment). The hydrolysis product isovaleric acid is acutely harmful to fish.
Hydrolysis product hydrochloric acid (HCl):
HCl was tested in a semi-static acute toxicity test according to OECD 203 with Cyprinus carpio. The 96-h LC50 was 4.92 mg/L (acid equivalent to pH 4.3; OECD, 2002).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.