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EC number: 416-140-4 | CAS number: 145650-60-8 IRGAFOS 38
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
There were no studies available in which the toxicokinetic properties of the test substance were investigated.
The test substance (molecular weight: 514.73 g/mol) is a white powder (Ciba-Geigy Ltd., 1982) with a log Pow = 11 (calculated, ACD/Labs software V11.02, BASF 2011), a water solubility of < 0.000021 g/L (Ciba-Geigy Ltd., 1993), and a vapour pressure of 0.000004 Pa at 25°C (Ciba-Geigy Ltd., 1992).
Absorption
Based on the physico-chemical properties, (very low water solubility and a log Pow of 11), the substance is not thought to be taken up by gastro-intestinal fluids very efficiently. In a subchronic capsule feeding study with dogs (Covance, 1999), the substance caused a functional adaption of the liver reflected in liver/gall bladder weight increases correlating with elevated alkaline phosphatase activity and centrilobular to diffuse hepatocellular hypertrophy (Ciba-Geigy, 1984). No other organs showed any effects up to the highest dose administered (1000 mg/kg). In a subchronic study with rats (C.I.T. 1994), the test substance did not cause any effects of toxicological relevance up to the highest dose tested (1000 mg/kg). The results from these two studies indicate a poor systemic availability of the test substance. In conclusion, the substance is not expected to be absorbed very well after oral administration. However, as indicated by the study performed in dogs, the substance has the potential to reach the liver at least partially, where it is probably eliminated as indicated by lack of toxic effects in both studies.
In an acute dermal toxicity study (Ciba-Geigy, 1992) and in a guinea pig maximization assay (Ciba-Geigy, 1993), no indications of systemic availability after dermal application were detected. Highly lipophilic substances that come into contact with the skin can readily penetrate the lipid rich stratum corneum but are not well absorbed systemically. Although they may persist in the stratum corneum, they will eventually be cleared as the stratum corneum is sloughed off. Furthermore, dermal uptake of chemicals with a molecular weight >500 is not favored (ECHA GD 7c, 2008). In conclusion, a dermal uptake of the test substance is expected to be low.
No reliable inhalation studies are available. However, given its very low vapor pressure and low water solubility, systemic availability after exposure to vapors or dust particle of the test substance is expected to be low.
Excretion
In view of the absence of relevant findings, it can be assumed that the test substance and its metabolites are rapidly excreted upon absorption after oral administration and liver passage. Since the test substance has a molecular weight larger than 500 g/mol and a low solubility in water, it is expected to be excreted predominantly via the faeces (ECHA GD 7c, 2008).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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