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Diss Factsheets
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EC number: 692-762-1 | CAS number: 166524-65-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Study period:
- Not reported
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Study conducted in accordance with generally accepted scientific principles; however full data on methodology is not given and no information relating to GLP status is provided. Furthermore, sufficient information on substance identity is not provided. An accurate assessment of the study is therefore not considered to be possible.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
- Report date:
- 1997
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- not specified
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Automatically generated during migration to IUCLID 6, no data available
- IUPAC Name:
- Automatically generated during migration to IUCLID 6, no data available
- Test material form:
- liquid: viscous
- Details on test material:
- - Name of test material (as cited in study report): 2-ethoxy-4,6-difluoropyrimidine (DFEP) tar bottoms
- Appearance: dark brown, viscous liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 2.766 - 2.793 kg
No further information is provided on test animals and environmental conditions.
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Preparation of test site: rabbits had their trunk clipped 24 hours prior to dosing
- Type of wrap if used: the applied test material was covered with an occluded wrap which, in turn, was covered by an elastic rabbit jacket
REMOVAL OF TEST SUBSTANCE
- Washing (if done): residual test material was wiped off when the bandage was removed after the exposure period
- Time after start of exposure: 24 hours after application - Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 2 males
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of weighing: animals were weighed on test days 1, 2, 8 and 15
- Necropsy of survivors performed: no data
- Other examinations performed: clinical signs and dermal irritation
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Both animals survived the test period.
- Clinical signs:
- other: No clinical signs of systemic toxicity were observed.
- Other findings:
- Both rabbits had erythema and oedema from test day 2 through test day 8. Scaling was noted on both rabbits from test day 8 through to study termination.
Any other information on results incl. tables
Table 1: Individual Body Weights (kg)
Animal |
Test day |
|||
1 |
2 |
8 |
15 |
|
1 |
2.766 |
2.954 |
3.119 |
3.259 |
2 |
2.793 |
2.868 |
2.805 |
2.923 |
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under the conditions of the study, the acute dermal LD50 of the test material was determined to be in excess of 2000 mg/kg.
- Executive summary:
The acute dermal toxicity of the test material was investigated in a study which was conducted to a method similar to that which is outlined in standardised guideline OECD 402.
During the study, 2000 mg/kg of neat test material was applied to the clipped trunks of 2 male New Zealand White rabbits under an occluded wrap which, in turn was covered with an elastic rabbit jacket. Residual test material was wiped off when the bandage was removed 24 hours after application. Both animals survived and both gained weight during the study. No clinical signs of systemic toxicity were observed. Both rabbits had erythema and oedema from test day 2 through test day 8. Scaling was noted on both rabbits from test day 8 through to study termination.
Under the conditions of the study, the acute dermal LD50 of the test material was determined to be in excess of 2000 mg/kg. As such, the test material requires no classification in accordance with EU criteria.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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