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Diss Factsheets
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EC number: 286-304-6 | CAS number: 85204-10-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
- Endpoint:
- basic toxicokinetics, other
- Type of information:
- other: expert statement
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Well documented expert statement based on a series of physicochemical and toxicology studies with WS400402.
- Objective of study:
- absorption
- Principles of method if other than guideline:
- Expert statement based on a series of physicochemical and toxicology studies with WS400402.
- Executive summary:
No specific study was performed on the absorption, distribution, metabolism, excretion (ADME) of this substance (WS400402), but data are currently available fromin vivoandin vitrotoxicology studies.
The test material, WS400402, is a complex mixture of components; their molecular weights range from 173 to 426 Da. The substance is well water soluble (456 g/L) and accordingly has low lipophilicity (Log10Pow< 1).
After oral administration WS400402 or components of this complex mixture are rapidly absorbed and systemically distributed leading to death after a single oral dose of 2000 mg/kg body weight in rats.
Systemic availability of WS400402 after dermal application is expected to be low based on its hydrophilicity. However, in view of the sensitization response attained in a Local Lymph Node Assay (LLNA) in mice at non-irritating test concentrations of WS400402 some dermal absorption must have occurred. This may have been only a small fraction of the administered test material.
Availability of WS400402 under a vapour state is unlikely, because of its low vapour pressure (3 x 10-4Pa at 25°C) and because it is a highly viscous liquid limiting its availability as an inhalable aerosol.
WS400402 or components of this complex mixture are rapidly absorbed and systemically distributed as was observed from effects in acute and repeated dose oral toxicity studies. There is no information on metabolism of WS400402.
There is no indication in the available study results regarding the excretion of WS400402 or components thereof.
Bioaccumulation of WS400402 is very unlikely based on the high hydrophilicity.
Reference
Description of key information
No specific study was performed on the absorption, distribution, metabolism, excretion (ADME) of this substance (WS400402), but data are currently available fromin vivoandin vitrotoxicology studies.
The test material, WS400402, is a complex mixture of components; their molecular weights range from 173 to 426 Da. The substance is well water soluble (456 g/L) and accordingly has low lipophilicity (Log10Pow< 1).
After oral administration WS400402 or components of this complex mixture are rapidly absorbed and systemically distributed leading to death after a single oral dose of 2000 mg/kg body weight in rats.
Systemic availability of WS400402 after dermal application is expected to be low based on its hydrophilicity. However, in view of the sensitization response attained in a Local Lymph Node Assay (LLNA) in mice at non-irritating test concentrations of WS400402 some dermal absorption must have occurred. This may have been only a small fraction of the administered test material.
Availability of WS400402 under a vapour state is unlikely, because of its low vapour pressure (3 x 10-4Pa at 25°C) and because it is a highly viscous liquid limiting its availability as an inhalable aerosol.
WS400402 or components of this complex mixture are rapidly absorbed and systemically distributed as was observed from effects in acute and repeated dose oral toxicity studies. There is no information on metabolism of WS400402.
There is no indication in the available study results regarding the excretion of WS400402 or components thereof.
Bioaccumulation of WS400402 is very unlikely based on the high hydrophilicity.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.