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EC number: 202-485-6 | CAS number: 96-17-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with acceptable restrictions (limited reporting on test substance and test performance)
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 974
- Report date:
- 1974
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 970
- Report date:
- 1970
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- : non fasted animals, limited reporting
- GLP compliance:
- no
- Remarks:
- pre-GLP study
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2-methylbutyraldehyde
- EC Number:
- 202-485-6
- EC Name:
- 2-methylbutyraldehyde
- Cas Number:
- 96-17-3
- Molecular formula:
- C5H10O
- IUPAC Name:
- 2-methylbutanal
- Details on test material:
- - Name of test material (as cited in study report): 2-methylbutyraldehyde
- no further information on test substance
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Carworth-Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: own breeding
- Age at study initiation: 4 to 5 weeks
- Weight at study initiation: 990 to 120 g
- Fasting period before study: no
- Housing: no data
- Diet (e.g. ad libitum): Rockland rat diet, complete
ENVIRONMENTAL CONDITIONS
- Temperature (°C): no data
- Humidity (%): no data
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): no data
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Details on oral exposure:
- Whenever possible, the test substance was administered undiluted.
- Doses:
- 4.0, 8.0, 16.0, and 32.0 mL/kg bw (3.2, 6.4, 12.9, and 25.7 g/kg bw)
Doses were arranged in a logarithnic series differing by a factor of two. - No. of animals per sex per dose:
- 5 (males)
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other: no data - Statistics:
- LD50 values were calculated by the method of Thompson (Thompson WR 1947, Bacteriol Rev 11, 115) using the Tables of Weil (Weil GS 1952, Biometrics 8, 249). The figures in parentheses show the limits of +/- 1.96 standard deviations.
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 6 884 mg/kg bw
- Remarks on result:
- other: ± 1.96 standard deviations (4274 - 11086 mg/kg bw ); values are converted from mL/kg bw as reported by authors.
- Mortality:
- 3200 mg/kg bw group 0/5
6400 mg/kg bw group 3/5
12900 mg/kg bw group 4/5
25700 mg/kg bw group 5/5 - Clinical signs:
- other: 12900 mg/kg bw group tremors and unsteady gait
- Gross pathology:
- congestion throughout the lungs and the abdominal viscera of the victims
Any other information on results incl. tables
The reported acute oral LD50 is 8.57 (5.32 - 13.8) mL/kg bw. The figures in parentheses show the limits of ± 1.96 standard deviations. Using a density of 0.8033 g/mL for 2 -methylbutyraldehyde, the LD 50 calculates to 6884 mg/kg bw (4274 - 11086 mg/kg bw).
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute oral LD50 of 2-methylbutyraldehyde is 6884 mg/kg bw in male rats. No classifcation is required according to EU legislation.
- Executive summary:
The acute oral toxicity of 2-methylbutyraldehyde was determined in groups of 5 male Carworth-Wistar rats receiving the test material by oral gavage at doses of 3.2, 6.4, 12.9, and 25.7 g/kg bw. The observation period was 14 days. The LD50 and a range of ± 1.96 SD was calculated according to the method of Thomson (1947). Overall the study was conducted in accordance with the recently retracted OECD test guideline 401.
The acute oral LD50 was determined to be 6884 mg/kg bw in rats (Carpenter, 1974).
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