1,2,4-Triazolo[4,3-c]pyrimidine-3(2H)-thione, 5-ethoxy-7-fluoro-

Particle size distribution (Granulometry)

Administrative data

Endpoint:

particle size distribution (granulometry)

Type of information:

experimental study

Adequacy of study:

key study

Study period:

Not reported

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Study conducted in accordance with generally accepted scientific principles, possibly with incomplete reporting or methodological deficiencies, which do not affect the quality or the relevance of results.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2013

Report date:

2013

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Particle size analysis was performed in support of dust explosion evaluation. Both 'as received' and sieved (<63 µm) material were analysed using a Particle Sizing System Accusizer 780 equipped with an LE400-0.5 sensor.

GLP compliance:

not specified

Type of distribution:

volumetric distribution

Test material

Test material information

Constituent 1

Reference substance name:

5-ethoxy-7-fluoro-2H,3H-[1,2,4]triazolo[4,3-c]pyrimidine-3-thione

EC Number:

695-186-9

Cas Number:

166524-68-1

Molecular formula:

C7H7FN4OS

IUPAC Name:

5-ethoxy-7-fluoro-2H,3H-[1,2,4]triazolo[4,3-c]pyrimidine-3-thione

Test material form:

other: dusty solid

Details on test material:

- Name of test material (as cited in study report): 4,3-TP
- Physical state: solid

Results and discussion

Particle size

Percentile:

D50

Remarks on result:

other: Migrated from fields under 'Mass median diameter' as D50 percentile. No source field for Standard deviation.

Any other information on results incl. tables

Table 1 Weight Fraction Analysis

Sample	Run	Weight % <63 µm (from sieve and Accusizer Analysis)	Weight % <250 µm (from sieve analysis)	Weight % 250 to 425 µm (from sieve analysis)	Weight % >425 µm (from sieve analysis)
<250 µm	1	8.2	56.5	2.5	40.9
	2	7.9
	3	8.5
	Average	8.2
Fike	1	85.0	-	-	-
	2	79.6
	3	79.6
	Average	81.4

 

Table 2 Accusizer Data

The data reported in Table 2 has been normalised to account for the fact that the sample contained material above 250 µm.

<250 µm Sieve - Run 1						Fike - Run 1
Diameter (microns)	Particle Count	Volume (%)	Cumulative Volume (%)	Normalised Volume (%)	Normalised Cumulative Volume (%)	Diameter (microns)	Particle Count	Volume (%)	Cumulative Volume (%)
1.08	15678	0	0.000	0.000	0.000	1.08	5816	0	0
1.19	15057	0	0.000	0.000	0.000	1.19	5407	0.001	0.001
1.32	13083	0	0.000	0.000	0.000	1.32	4363	0.001	0.002
1.46	12143	0	0.000	0.000	0.000	1.46	3840	0.001	0.003
1.62	10692	0	0.000	0.000	0.000	1.62	3336	0.001	0.004
1.80	8934	0.001	0.001	0.001	0.001	1.80	2696	0.001	0.005
1.99	7480	0.001	0.002	0.001	0.001	1.99	2395	0.001	0.006
2.21	6200	0.001	0.003	0.001	0.002	2.21	2083	0.001	0.007
2.44	5361	0.001	0.004	0.001	0.002	2.44	1952	0.002	0.009
2.71	4683	0.001	0.005	0.001	0.003	2.71	1700	0.002	0.011
3.00	4338	0.001	0.006	0.001	0.003	3.00	1644	0.003	0.014
3.32	3972	0.002	0.008	0.001	0.005	3.32	1660	0.004	0.018
3.68	3710	0.002	0.010	0.001	0.006	3.68	1651	0.005	0.023
4.08	3495	0.003	0.013	0.002	0.007	4.08	1618	0.007	0.030
4.52	3378	0.003	0.016	0.002	0.009	4.52	1885	0.011	0.041
5.00	3378	0.005	0.021	0.003	0.012	5.00	1974	0.015	0.056
5.54	3411	0.006	0.027	0.003	0.015	5.54	2220	0.023	0.079
6.14	3306	0.008	0.035	0.005	0.020	6.14	2559	0.037	0.116
6.80	3091	0.011	0.046	0.006	0.026	6.80	2765	0.054	0.170
7.53	2843	0.013	0.059	0.007	0.033	7.53	3153	0.083	0.253
8.35	2551	0.016	0.075	0.009	0.042	8.35	3461	0.124	0.377
9.25	2253	0.019	0.094	0.011	0.053	9.25	3849	0.188	0.565
10.24	1970	0.023	0.117	0.013	0.066	10.24	4113	0.272	0.837
11.35	1669	0.027	0.144	0.015	0.081	11.35	4573	0.412	1.25
12.57	1349	0.029	0.173	0.016	0.098	12.57	4677	0.573	1.82
13.92	1136	0.033	0.206	0.019	0.116	13.92	4800	0.799	2.62
15.42	1015	0.041	0.247	0.023	0.140	15.42	4734	1.071	3.69
17.09	827	0.045	0.292	0.025	0.165	17.09	4675	1.438	5.13
18.93	714	0.053	0.345	0.030	0.195	18.93	4237	1.772	6.90
20.97	712	0.072	0.417	0.041	0.236	20.97	3972	2.258	9.16
23.23	652	0.089	0.506	0.050	0.286	23.23	316	2.872	12.0
25.73	597	0.111	0.617	0.063	0.349	25.73	3348	3.517	15.5
28.51	700	0.177	0.794	0.100	0.449	28.51	3047	4.352	19.9
31.58	798	0.274	1.07	0.155	0.603	31.58	2762	5.363	25.3
34.98	923	0.432	1.50	0.244	0.848	34.98	2507	6.617	31.9
38.75	1056	0.671	2.17	0.379	1.23	38.75	2208	7.923	39.8
42.93	1267	1.095	3.27	0.619	1.85	42.93	1744	8.508	48.3
47.56	1260	1.48	4.75	0.836	2.68	47.56	1392	9.231	57.5
52.68	1535	2.452	7.20	1.39	4.07	52.68	1176	10.602	68.1
58.36	1681	3.65	10.8	2.06	6.13	58.36	843	10.332	78.5
64.65	1691	4.991	15.8	2.82	8.95	64.65	527	8.781	87.3
71.62	1685	6.761	22.6	3.82	12.8	71.62	266	6.025	93.3
79.34	1608	8.771	31.4	4.96	17.7	79.34	103	3.172	96.5
87.89	1207	8.951	40.3	5.06	22.8	87.89	46	1.926	98.4
97.36	936	9.436	49.8	5.33	28.1	97.36	18	1.024	99.4
107.85	650	8.908	58.7	5.03	33.1	107.85	5	0.387	99.8
119.48	421	7.844	66.5	4.43	37.6	119.48	2	0.21	100
132.36	272	6.889	73.4	3.89	41.5	132.36	0	0	100
146.62	141	4.855	78.3	2.74	44.2	146.62	0	0	100
162.43	116	5.43	83.7	3.07	47.3	162.43	0	0	100
179.93	81	5.154	88.8	2.91	50.2	179.93	0	0	100
199.33	38	3.287	92.1	1.86	52.1	199.33	0	0	100
220.81	19	2.234	94.4	1.26	53.3	220.81	0	0	100
244.61	17	2.718	97.1	1.54	54.8	244.61	0	0	100
270.97	8	1.739	98.8	0.983	55.8	270.97	0	0	100
300.18	4	1.182	100	0.668	56.5	300.18	0	0	100
330.41	0	0	10	0.000	56.5	330.41	0	0	100

Applicant's summary and conclusion

Conclusions:

Weight fraction analysis of the ‘as received’ sample resulted in a weight % <63 µm (from sieve and Accusizer Analysis) of 8.2. The following values were obtained from sieve analysis only: weight % <250 µm was 56.5; weight % 250 to 425 µm was 2.5; weight % >425 µm was 40.9.
Weight fraction analysis of the Fike sample resulted in a weight % <63 µm (from sieve and Accusizer Analysis) of 81.4.

Executive summary:

Particle size analysis was performed in support of dust explosion evaluation. Both 'as received' and sieved (<63 µm) material were analysed using a Particle Sizing System Accusizer 780 equipped with an LE400-0.5 sensor.

The 'as received' samples were sieved using a 425 µm sieve in order to determine the weight percent less than 425 µm. An additional sieve analysis was performed to remove particles greater than 250 µm and the less than 250 µm portion of the sample was analysed using the Accusizer particle size analyser.

The Accusizer data was combined with the sieve analyses to obtain the weight percent of the samples less than 63 µm and the size distribution of those particles less than 63 µm.

 

Weight fraction analysis of the ‘as received’ sample resulted in a weight % <63 µm (from sieve and Accusizer Analysis) of 8.2.

The following values were obtained from sieve analysis only: weight % <250 µm was 56.5; weight % 250 to 425 µm was 2.5; weight % >425 µm was 40.9.

Weight fraction analysis of the Fike sample resulted in a weight % <63 µm (from sieve and Accusizer Analysis) of 81.4.