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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 229-552-2 | CAS number: 6606-65-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
EYE IRRITATION:
- REACH_Lit_effective ophtalmological method | human | Clinical Experience with n-butyl cyanaoacrylate (Leahey et al) |
- REACH_Lit_effective alternative to sutures | human | Efficacy of bioadhesives in scleral tunnel phacoemulsification in eyes (Alio et al) |
- REACH_Lit_safe healing technique | human | Clinical experience with cyanoacrylate tissue adhesive (Moschos et al) |
- REACH_Lit_effective dental treatment | human | Treating Dentin Hypersensitivity (Perez et al) |
- REACH_Lit_highly effective | human | Effectiveness of Isobutyl Cyanoacrylate for Treatment of Corneal Perforations (Setlik) | #Analogy#
Additional information
Exposure related observations in humans - Literature with regard to eye irritation
Much experience from clinical observations and investigations in humans is available.
Various authors describe that the use of n-butyl cyanoacrylate (as well as the structural analogue isobutyl cyanoacrylate) offers a safe technique for healing corneal wounds and is an effective alternative to classical sutures (e.g. in scleral tunnel cataract surgery or for treatment of corneal perforations). The case reports and clinical studies describe a direct application of the adhesive onto the eye (cornea) which gives an indication on the compatibility of the tissue adhesive on eyes. It is summarized that n-butyl cyanoacrylate can well be used as wound barrier in ocular surgery with a low side effect profile. Irritation was not mentioned in any of the publications as contraindication for the use of n-butyl cyanoacrylate in eye surgery.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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