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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
adsorption / desorption: screening
Type of information:
calculation (if not (Q)SAR)
Remarks:
Migrated phrase: estimated by calculation
Adequacy of study:
key study
Study period:
2008
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: key study, experimental results

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2008
Report date:
2008

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
HPLC estimation method
Media:
soil/sewage sludge

Test material

Constituent 1
Chemical structure
Reference substance name:
N-(1-oxooctyl)glycine
EC Number:
238-122-3
EC Name:
N-(1-oxooctyl)glycine
Cas Number:
14246-53-8
Molecular formula:
C10H19NO3
IUPAC Name:
N-(1-oxooctyl)glycine
Details on test material:
Name of test material (as cited in study report): LCA08030
- Substance type: mono-constituant
- Physical state: solid
- Analytical purity: >97%
- Lot/batch No.: 0814300007
- Storage condition of test material: In darkness at room temperature

Study design

Test temperature:
The temperature during the analytical phase was around 22°C.

HPLC method

Details on study design: HPLC method:
The experimental method uses HPLC for the estimation of the adsorption coefficient
Koc in soil and in sewage sludge.
HPLC is performed on a column packed with a cyanopropyl phase containing
lipophilic and polar moieties. While passing through the volume along with the mobile phase,
the test substance interacts with the stationary phase. The dual-composition of the stationary
phase having polar and non-polar sites allows for interaction of polar and non-polar groups of
a molecule in a similar way as is the case for organic matter in soil or sewage sludge
matrices. This enable the relationship between the retention time on the column and the
adsorption coefficient on organic matter to be established.

Batch equilibrium or other method

Analytical monitoring:
yes
Computational methods:
- Adsorption and desorption coefficients (Kd):

Results and discussion

Adsorption coefficient
Type:
log Koc
Value:
< 1.25

Results: HPLC method

Details on results (HPLC method):

- Average retention data for test substance:2.06

Any other information on results incl. tables

the test item peak showed nearly no retention on the column and no reference item with lower retention time was avalaible.

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Remarks:
The adsorption / desorption coefficient of LCA08030 is lower then 1.25.
Conclusions:
The adsorption / desorption coefficient of LCA08030 is lower then 1.25.
Executive summary:

The objective of this study was to estimate the adsorption/desorption coefficient on soil and on sewage sludge using (HPLC) High Performance Liquid Chromatography following the test method (OECD Guideline No. 121, 2001). Using this procedure, it was shown that the adsorption / desorption coefficient of LCA08030 is lower then 1.25.