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EC number: 238-122-3 | CAS number: 14246-53-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Adsorption / desorption
Administrative data
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- calculation (if not (Q)SAR)
- Remarks:
- Migrated phrase: estimated by calculation
- Adequacy of study:
- key study
- Study period:
- 2008
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: key study, experimental results
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
- Report date:
- 2008
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC estimation method
- Media:
- soil/sewage sludge
Test material
- Reference substance name:
- N-(1-oxooctyl)glycine
- EC Number:
- 238-122-3
- EC Name:
- N-(1-oxooctyl)glycine
- Cas Number:
- 14246-53-8
- Molecular formula:
- C10H19NO3
- IUPAC Name:
- N-(1-oxooctyl)glycine
- Details on test material:
- Name of test material (as cited in study report): LCA08030
- Substance type: mono-constituant
- Physical state: solid
- Analytical purity: >97%
- Lot/batch No.: 0814300007
- Storage condition of test material: In darkness at room temperature
Constituent 1
Study design
- Test temperature:
- The temperature during the analytical phase was around 22°C.
HPLC method
- Details on study design: HPLC method:
- The experimental method uses HPLC for the estimation of the adsorption coefficient
Koc in soil and in sewage sludge.
HPLC is performed on a column packed with a cyanopropyl phase containing
lipophilic and polar moieties. While passing through the volume along with the mobile phase,
the test substance interacts with the stationary phase. The dual-composition of the stationary
phase having polar and non-polar sites allows for interaction of polar and non-polar groups of
a molecule in a similar way as is the case for organic matter in soil or sewage sludge
matrices. This enable the relationship between the retention time on the column and the
adsorption coefficient on organic matter to be established.
Batch equilibrium or other method
- Analytical monitoring:
- yes
- Computational methods:
- - Adsorption and desorption coefficients (Kd):
Results and discussion
Adsorption coefficient
- Type:
- log Koc
- Value:
- < 1.25
Results: HPLC method
- Details on results (HPLC method):
- Average retention data for test substance:2.06
Any other information on results incl. tables
the test item peak showed nearly no retention on the column and no reference item with lower retention time was avalaible.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Remarks:
- The adsorption / desorption coefficient of LCA08030 is lower then 1.25.
- Conclusions:
- The adsorption / desorption coefficient of LCA08030 is lower then 1.25.
- Executive summary:
The objective of this study was to estimate the adsorption/desorption coefficient on soil and on sewage sludge using (HPLC) High Performance Liquid Chromatography following the test method (OECD Guideline No. 121, 2001). Using this procedure, it was shown that the adsorption / desorption coefficient of LCA08030 is lower then 1.25.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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