Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: - | CAS number: 42355-78-2
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
EC50 48h Daphnia magna > 100 mg/l
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 100 mg/L
Additional information
No specific tests on the substance under registration are available, nevertheless available data on the similar substances 1 -DSA and 3a-MSA are available and are used for the evaluation of the short-term toxicity of the substance to aquatic invertebrates.
Justification for Read Across is given in Section 13 of IUCLID.
In two GLP studies the 1 -DSA was tested at 24 and 48 h on Daphnia magna with EC50 > 100 mg/l (Ciba-Geigy Ltd., 1996 and Springborn Smithers Laboratories, 2008, respectively).
Acute toxicity for Daphnia magna was also investigated on the analogous 3a-MSA in a 48 hours screening test, according to the OECD guideline 202. A single dose was administrated at 100 mg/l (limit test) with no effect (Bayer AG., 2000). The result was confirmed by two further supporting studies: one performed at just 24h (RCC Umweltchemie AG., 1988) and the other one at 48 but just the summary is available (Solvias AG. 1999), with no effect up to 1000 mg/l.
As a consequence it can be concluded that no short term toxicity to aquatic invertebrates is expected also for 1 -MSA. The result of the key study is taken as a reference for risk assessment.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
