Registration Dossier
Registration Dossier
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EC number: 230-786-2 | CAS number: 7320-37-8
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
In a GLP complaint Local Lymph Node Assay, according to OECD guideline 429, the potential to cause skin sensitization was assessed by applying the test substance Decyloxirane to the dorsal skin of CBA mice at concentrations of 2, 5 an 10% dissolved in acetone/olive oil (4:1 v/v).The highest concentration tested was the highest concentration that could be achieved whilst avoiding systemic toxicity and excessive local skin irritation (as determined by two pre-experiments). In this study Stimulation Indices (S.I.) of 0.68, 0.92, and 2.92 were determined with the test item at concentrations of 2, 5, and 10% in acetone/olive oil (4+1, v/v), respectively. A dose response was observed. The EC3 value could not be calculated, since none of the tested concentrations induced a S.I. greater than the threshold value of 3. The test substance was therefore not considered to be a skin sensitizer.
Migrated from Short description of key information:
The test substance was not skin sensitizing in a LLNA study.
Justification for selection of skin sensitisation endpoint:
There is only one study available.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
The test substance was not skin sensitizing in the LLNA study. Classification for skin sensitization is therefore not warranted in accordance with EU Classification, Labeling and Packaging of Substances and Mixtures (CLP) Regulation No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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