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Diss Factsheets
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EC number: 258-053-2 | CAS number: 52628-03-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vitro / ex vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 2012
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific standards, well-documented and acceptable for assessment
Cross-reference
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
- Objective of study:
- other: HYDROLYSIS OF PHOSPHOETHYL METHACRYLATE DIESTER AND PHOSPHOETHYL METHACRYLATE MONOESTER
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- no
Test material
- Reference substance name:
- Phosphoethyl methacrylate monoester
- IUPAC Name:
- Phosphoethyl methacrylate monoester
- Reference substance name:
- Phosphoethyl methacrylate diester
- IUPAC Name:
- Phosphoethyl methacrylate diester
- Test material form:
- not specified
- Details on test material:
- - Name of test material (as cited in study report): phosphoethyl methacrylate monoester
- Lot/batch No.: MKBG8354
- Name of test material (as cited in study report): phosphoethyl methacrylate diester
- Lot/batch No.: MKBJ7438V
- Name of test material (as cited in study report): pure phosphoethyl methacrylate monoester
- Lot/batch No.: QM1326 (DCC-6363)
Constituent 1
Constituent 2
- Radiolabelling:
- no
Test animals
- Species:
- other: not applicable
- Details on test animals or test system and environmental conditions:
- not applicable
Administration / exposure
- Route of administration:
- other: not applicable
- Vehicle:
- unchanged (no vehicle)
- Details on exposure:
- Phosphoethyl methacrylate monoester or Phosphoethyl methacrylate diester at two concentrations (0.1 mM and 1 mM) ) was individually incubated
for 45 minutes with rat liver microsomes, or human liver S9, or rat liver S9 (1 mg/mL protein) in the presence or absence of cofactor NADPH (1 mM) under the physiological condition (pH 7.4 with 0.1 M phosphate buffer and 37°C). - Duration and frequency of treatment / exposure:
- 45 minutes
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.1 mM and 1 mM
- No. of animals per sex per dose / concentration:
- not applicable
- Control animals:
- other: not applicable
- Positive control reference chemical:
- no
- Details on study design:
- Phosphoethyl methacrylate monoester or Phosphoethyl methacrylate diester at two concentrations (0.1 mM and 1 mM) ) was individually incubated for 45 minutes with rat liver microsomes, or human liver S9, or rat liver S9 (1 mg/mL protein) in the presence or absence of cofactor NADPH (1 mM) under the physiological condition (pH 7.4 with 0.1 M phosphate buffer and 37C). After incubation, the sample were taken out from the incubator and put in ice-bath and 200 uL of Acetonitrile containing 2% formic acid was added to each incubation vial. After a vortex, the whole solution was transferred to a microcentriguge tube and centrifuged for 5 min at 15000 rpm. The supernatant was transferred to a clean glass vial for Q-TOF LC/MS analysis of substrate loss or the hydrolysis metabolite formation.
- Statistics:
- Phosphoethyl methacrylate monoester or Phosphoethyl methacrylate diester at two concentrations (0.1 mM and 1 mM) ) was individually incubated for 45 minutes with rat liver microsomes, or human liver S9, or rat liver S9 (1 mg/mL protein) in the presence or absence of cofactor NADPH (1 mM) under the physiological condition (pH 7.4 with 0.1 M phosphate buffer and 37C). After incubation, the sample were taken out from the incubator and put in ice-bath and 200 uL of Acetonitrile containing 2% formic acid was added to each incubation vial.
Results and discussion
- Preliminary studies:
- not applicable
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- not applicable
- Details on distribution in tissues:
- not applicable
- Details on excretion:
- not applicable
Metabolite characterisation studies
- Details on metabolites:
- not applicable
Bioaccessibility (or Bioavailability)
- Bioaccessibility (or Bioavailability) testing results:
- not applicable
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): other: phosphoethyl methacrylate diester (diester) and phosphoethyl methacrylate monoester (monoester) are stable in the presence of rat or human liver tissue enzymes
The current study showed that both phosphoethyl methacrylate diester (diester) and phosphoethyl methacrylate monoester (monoester) are stable in the presence of rat or human liver tissue enzymes. - Executive summary:
To explore the enzymatic hydrolysis rates of both phosphoethyl methacrylate diester (diester) and phosphoethyl methacrylate monoester (monoester), two concentrations of diester and monoester(0.1 mM, 1mM) were incubated for 45 minutes with commercial rat liver microsomes, mouse liver S9, and human liver S9 (1 mg /mL) in the presence or absence of the cofactor NADPH (1 mM) under physiological condition (pH 7.4 with 0.1 M phosphate buffer and 37°C). Following by enzyme deactivation and, centrifugation, levels of the parent esters were determined by high resolution Q-TOF/LC/MS analysis. Analysis results showed that both diester and monoester were poorly hydrolyzed in the current incubation condition, indicating that both diester and monoester are stable in current in vitro enzymatic hydrolysis condition.
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