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Diss Factsheets
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EC number: 263-974-8 | CAS number: 63157-72-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
Since no toxicokinetic studies are available for ethylviolet acetate the following assessment is based on the available physicochemical properties and results from other toxicological studies:
The substance is a solid, green violet homogeneous mass with a partition coefficient (log Kow) of 2.374 at 25 °C. Based on this rather low partition coefficient the test substance is unlikely to bioaccumulate with the repeated intermittent exposure patterns normally encountered. The substance has a very low vapour pressure (0.0000026 hPa at 20 °C and 0.0000053 hPa at 25 °C).
Acute oral toxicity studies in rats provide evidence for systemic availability of ethylviolet acetate by the oral route (based on the observed colored organs and tissues, clinical symptoms and the LD50 of 410 mg/kg bw).
The positive result of a local lymph node assay in mice with application of the test substance to the intact skin suggests that dermal uptake of the test substance might occur to a certain extent.
The severe signs of toxicity observed in a 28-day repeated dose toxicity study by oral application (gavage) in rats indicate systemic availability of ethylviolet acetate by this exposure route. Furthermore, in this study a blue discoloration was observed macroscopically in carcass, organs and gastrointestinal contents indicative for distribution of ethylviolet acetate to these organs and tissues. Supportingly, in a prenatal developmental toxicity study in rats by oral application (gavage) blue or dark discolorations were found in a number of organs/tissues at necropsy. These discolorations mirror the systemic availability of the test substance or its metabolites.
The results from several in vitro genotoxicity studies with and without metabolic activation indicate that no reactive metabolite was formed after the addition of rat liver S9 mix.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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