Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 260-375-3 | CAS number: 56773-42-3
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Limited documentation, no data on compound purity, animals were dosed at the ear for 24 hours
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
- Principles of method if other than guideline:
- 2 white New-Zealand rabbits were treated onto the inside of the ear with ca. 500 mg of the test substance. The test item remained under semiocclusion for 24 hours. Treated animals were inspected for skin effects (erythma, oedema) after removal of plaster and after 1, 4, 5 and 7 days. Total observation time was 7 days.
- GLP compliance:
- no
Test material
- Reference substance name:
- Tetraethylammonium heptadecafluorooctanesulphonate
- EC Number:
- 260-375-3
- EC Name:
- Tetraethylammonium heptadecafluorooctanesulphonate
- Cas Number:
- 56773-42-3
- Molecular formula:
- C8H20N.C8F17O3S
- IUPAC Name:
- N,N,N-triethylethanaminium 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluorooctane-1-sulfonate
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- other: hairless skin of rabbit ear
- Vehicle:
- not specified
- Controls:
- not required
- Duration of treatment / exposure:
- exposition: 24 hours
- Observation period:
- 7 days
- Number of animals:
- 2 (1 male + 1 female)
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: after removal, 1, 4. 5, 7 days
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable (score = 0 at any time point)
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: after removal, 1, 4, 5, 7 days
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable (score = 0 at any time point)
- Other effects:
- no data
Any other information on results incl. tables
no data
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information
- Executive summary:
2 white New-Zealand rabbits were treated onto the inside of the ear with ca. 500 mg of the test substance. The test item remained under semiocclusion for 24 hours. Treated animals were inspected for skin effects (erythma, oedema) after removal of plaster and after 1, 4, 5 and 7 days. Total observation time was 7 days.
Score = 0 at any time point; no skin irritation was found on the ear after removal of the test substance/plaster.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
