Registration Dossier
Registration Dossier
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EC number: 229-633-2 | CAS number: 6635-20-7
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
Data source
Reference
- Reference Type:
- publication
- Title:
- Problem of the toxicity of vanillin
- Author:
- Makaruk MI
- Year:
- 1 980
- Bibliographic source:
- Gig Sanit, 6, 78-80
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Vanillin
- EC Number:
- 204-465-2
- EC Name:
- Vanillin
- Cas Number:
- 121-33-5
- Molecular formula:
- C8H8O3
- IUPAC Name:
- 1-butoxypropan-2-ol
Constituent 1
Test animals
- Species:
- guinea pig
- Strain:
- not specified
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- shaved
- Vehicle:
- other: undiluted or in saturated acetone solution
- Controls:
- not specified
- Duration of treatment / exposure:
- 2 years
- Details on study design:
- TEST SITE: no data
REMOVAL OF TEST SUBSTANCE:
- Washing: yes
- Time after start of exposure: 2 hours
SCORING SYSTEM: no data
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Remarks on result:
- other: slightly irritating
Applicant's summary and conclusion
- Interpretation of results:
- slightly irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- When vanillin was applied as a powder, skin irritation (erythema of 2nd degree) was observed immediately after exposure, and disappears after
5-6 hours. No such effect was observed with a saturated solution in acetone - Executive summary:
When vanillin was applied as a powder, skin irritation (erythema of 2nd degree) was observed immediately after exposure, and disappears after 5-6 hours. No such effect was observed with a saturated solution in acetone
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