4-tert-butylbenzaldehyde

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Meets generally accepted scientific principles with acceptable deviations.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1981

Report date:

1981

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 402 (Acute Dermal Toxicity)

Principles of method if other than guideline:

The study was conducted according to an internal BASF method.

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

4-tert-butylbenzaldehyde

EC Number:

213-367-9

EC Name:

4-tert-butylbenzaldehyde

Cas Number:

939-97-9

Molecular formula:

C11H14O

IUPAC Name:

4-tert-butylbenzaldehyde

Details on test material:

- Name of test material (as cited in study report): p-Tertiaerbutyl-benzaldehyde
- Analytical purity: 98 %

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Weight at study initiation: males: ca. 225 g; females: ca. 174 g

Administration / exposure

Type of coverage:

not specified

Vehicle:

water

Details on dermal exposure:

TEST SITE
- Area of exposure: ca. 50 cm2

TEST MATERIAL
- Concentration: 25 (200 mg/kg bw), 50 (400 mg/kg bw) or 100 % (1000 and 2000 mg/kg bw) of the test substance in vehicle

Duration of exposure:

24 h; the test material was not rinsed.

Doses:

200, 400, 1000 and 2000 mg/kg bw

No. of animals per sex per dose:

3 animals per sex per dose

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days.
- Frequency of observations and weighing: The animals were weighed prior to exposure of the test material, on day 2, 7 and on day 13 and observed for clinical signs on working days.
- Necropsy performed: yes

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 2 000 mg/kg bw

Mortality:

1/6 animals of the 2000 mg/kg dose group died within the first two days.
All other animals survived.

Clinical signs:

other: 2000 mg/kg : dyspnea, apathy, tremor, diarrhea, generally bad condition 1000 mg/kg : dyspnea, apathy, aggressiveness ; staggering, spastic movement, morphine tail, generally bad condition 400 mg/kg : dyspnea, apathy, excitation, staggering, spastic moveme

Gross pathology:

Dead animal:
Heart: acute dilatation on the right side; acute congestion hyperemia.
Lung: acute and moderate exhalation.
Liver: brightened, clay-like coloured, broadened Lobuli hepatici.

Sacrificed animals:
No substance-related effects.

Other findings:

Local irritation effects:
2000 mg/kg: after 24 hours very slight redness and slight edema;
1000 - 200 mg/kg: skin partly splotched and anaemic, slight edema.

All observations were reversible within 7 d.