Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 220-822-5 | CAS number: 2909-38-8
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- repeated dose toxicity: oral
- Remarks:
- other: 14 days, repeated dose study
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: No OECD Guideline or GLP defined; insufficient data documentation.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 960
- Report date:
- 1960
Materials and methods
- Principles of method if other than guideline:
- oral repeated dose study in male rats.
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- 3-chlorophenyl isocyanate
- EC Number:
- 220-822-5
- EC Name:
- 3-chlorophenyl isocyanate
- Cas Number:
- 2909-38-8
- Molecular formula:
- C7H4ClNO
- IUPAC Name:
- 1-chloro-3-isocyanatobenzene
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: oil
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 14 d
- Frequency of treatment:
- once daily
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.1 ccm/kg bw
Basis:
other: 1% in oil
- No. of animals per sex per dose:
- 10
- Control animals:
- no
Results and discussion
Effect levels
- Dose descriptor:
- NOEL
- Effect level:
- > 0.1 other: ccm/kg bw.
- Sex:
- male
- Basis for effect level:
- other: No signs of toxicity or a disorganization of the general condition or the body weight could be observed during the 14 days of administration or in the observation period (period not defined).
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
No signs of toxicity or a disorganization of the general condition or the body weight could be observed during the 14 days of administration or in the observation period (period not defined).
Applicant's summary and conclusion
- Executive summary:
In a 14 day oral repeated dose toxicity study in 10 male rats the test animals received the test substance at a dose of 0.1 ccm/kg bw. via gavage once, daily.
No signs of toxicity or a disorganization of the general condition or the body weight could be observed during the 14 days of administration or in the observation period (period not defined).
Therefore the NOEL was > 0.1 ccm/kg bw.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
