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EC number: 407-950-9 | CAS number: 895-85-2 INTEROX-PMBP-70W; INTEROX-PMPB-70W
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 7-9 October 1991
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Well conducted GLP study, according to OECD and EU guidelines, purity mentioned.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- Adopted May 12, 1981
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- September 1984
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- column elution method
- Water solubility:
- 0.043 mg/L
- Temp.:
- 20 °C
- pH:
- 6
- Conclusions:
- The water solubility of bis(4-methylbenzoyl)peroxide at 20°C is 0.043mg/L.
- Executive summary:
The determination of the water solubility was based on OECD Guideline No.105 Water solubility (column elution method - flask method) (1981) and EEC directive A.6 Water solubility(1984), using the column elution method.
The water solubility of bis(4-methylbenzoyl)peroxide at 20°C is 0.043mg/L.
Reference
A schematic flowchart of the on-line system used is shown in Figure 1in the attachment. Representative HPLC chromatograms of a standard solution of DI-(4-METHYLBENZOYL)-PEROXID (INTEROX-PMBP), a water sample from Column I and a water sample from the blank column (Column IV) are shown in Figures 2, 3 and 4, respectively in the attachment.
The chromatograms of the water samples showed a number of peaks around the main component of the test substance. Whether these additional peaks represent possible degradation products andlor impurities with relatively high water solubility, was nor further investigated.
The chromatograms of the samples taken from the blank column at 20.0 ± 0.5°C did not-show any peak with the same retention as the test substance.
The water solubility estimated from preliminary test 1 was 6x10-6g/L
The water solubility estimated from preliminary test 2 was 4.9x10-5g/L at 21.0 ± 0.5°C (individual measurements not shown).
The results of the individual measurements of the first experiment (Column I) and the third experiment (Column III) of the main study are summarized in Table 1 and 2, respectively.
The mean water solubility, as determined for Column II, was 4.6x10-5and 5.3x10-5g/L at a flowrate of 23 and 12 ml/hour, respectively (further details not reported). Because the maximum deviation was 32 % at both flowrates, an additional experiment (i.e. Column III) was carried out.
The water solubility of the test substance was calculated to be 4.3x 10-5g/l, as the mean value of the water solubilities as determined during the first experiment (Column I) and the third experiment (Column III). The maximum deviation between both water solubilities was calculated to be 14%. During the first experiment as well as during the second experiment, the coefficient of variation of at least 5 consecutive samples at each flowrate was<30%. The maximum deviation between the water solubilities as determined during the high and low flowrate was<30% for both experiments.The maximum deviation between the water solubilities of both experiments was<30%. According to the guidelines (OECD, EEC), the test was considered to be valid.
In conclusion, the water solubility of DI-(4-METHYLBENZOYL)-PEROXID (INTEROX-PMBP) at 20.0±0.5°Cwas determined to be 4.3x10-5g/L, using the column elution method.
Description of key information
The water solubility of bis(4-methylbenzoyl)peroxide at 20°C is 0.043mg/L.
Key value for chemical safety assessment
- Water solubility:
- 0.043 mg/L
- at the temperature of:
- 20 °C
Additional information
Experimentally determined water solubility is 0.043 mg/L (insoluble, < 0.1 mg/L).
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