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EC number: 931-210-9 | CAS number: 1266534-73-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
oral: LD50 (rat) > 2000 mg/kg bw
dermal: LD50 (rat) > 2000 mg/kg bw
inhalation: LC50 not determined, as study technically not feasible
Key value for chemical safety assessment
Additional information
In an acute oral toxicity study which was conducted according to OECD guideline 423, Aluminium silicate and titanium oxide matrix doted with vanadium, nickel, and antimony was administered to a group of six female Sprague Dawley rats at the limit dose of 2000 mg/kg bw (Richeux 2010, RL1). No mortality occured during the study. No clinical signs related to the administration of the test material were observed. The body weight evolution of the animals remained normal throughout the study. The macroscopic examinations of the animals at the end of the study did not reveal any treatment-related changes. In conclusion, the LD 50 was > 2000 mg/kg bw by oral route in the rat.
In an acute dermal toxicity study which was conducted according to OECD guideline 402, Aluminium silicate and titanium oxide matrix doted with vanadium, nickel, and antimony was applied onto the intact skin of 5 male and 5 female Sprague Dawley rats at the limit dose of 2000 mg/kg bw (Richeux 2010, RLl). No mortality occured during the study. Neither cutaneous reactions nor systemic clinical signs related to the administration of the test material were observed. The body weight evolution of the animals remained normal throughout the study. The macroscopical examination of the animals at the end of the study did not reveal any treatment-related changes. In conclusion, the LD 50 was > 2000 mg/kg bw by dermal route in the rat.
Preliminary investigations aiming at creating a sufficiently respirable test atmosphere of Aluminium silicate and titanium oxide matrix doted with vanadium, nickel, and antimony (Weniger, 2010, RL1) demonstrated that the test material cannot be dispersed into a test atmosphere that fulfils the requirements of OECD 403 and its related guidelines. Since state-of-the-art dust generation techniques were employed to no avail, it is concluded that Aluminium silicate and titanium oxide matrix doted with vanadium, nickel, and antimony is not capable of forming respirable dust. The dust generated in the various preliminary experiments contained a respirable fraction (1-4 µm) of only about 1%.
Aluminium silicate and titanium oxide matrix doted with vanadium, nickel, and antimony therefore has an inherently low exposure potential to the alveolar region of the lung.
Additional data for acute toxicity are available for the following source substances which serve as potential data sources for the analogue approach of Aluminium silicate and titanium oxide matrix doted with vanadium, nickel, and antimony:
For the oral as well as for the dermal route, the LD 50 for all available data was found to be at least > 2000 mg/kg bw:
- Source chemical 1 - Fluidized catalytic cracking (FCC) catalysts:
LD50 oral > 31600 mg/kg bw/d (S); Calkins and Ward 1976
LD50 dermal > 2000 mg/kg bw/d (S); Calkins and Ward 1976
- Source chemical 2 - Zeolite, cuboidal, crystalline, synthetic, non-fibrous:
LD50 oral > 5110 mg/kg bw (K); Berthold 1990
LD50 oral > 31600 mg/kg bw (S); WR Grace and Company 1976
LD50 dermal > 2000 mg/kg bw (K); Moore 1974
LD50 dermal > 2000 mg/kg bw (S); WR Grace and Company 1976
- Source chemical 3 - Kaolin, calcined:
LD50 oral > 5000 mg/kg bw (K); Wnorowski 1997
LD50 dermal > 5000 mg/kg bw (K); Wnorowski 1997
- Source chemical 4 - Silicic acid, aluminium salt:
LD50 oral > 2000 mg/kg bw (K); Colas 2009
- Source chemical 5 - Aluminium oxide:
LD50 oral > 15900 mg/kg bw (K); Butter 1969
The available data support the applicability of the selected substances within the analogue approach of Aluminium silicate and titanium oxide matrix doted with vanadium, nickel, and antimony.
As the respirability of Aluminium silicate and titanium oxide matrix doted with vanadium, nickel, and antimony can be excluded, no data are provided for the source substances for the analogue approach.
The respective references for the source substance data can be found in the data matrix of the justification for the analogue approach, which can be found either in the CSR or as attachment in IUCLID section 13.
Justification for classification or non-classification
Based on the results obtained, Aluminium silicate and titanium oxide matrix doted with vanadium, nickel, and antimony does not fulfill the criteria to be classified for acute toxicity according to DSD (67/548/EEC) or CLP (1272/2008/EC).
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