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Diss Factsheets
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EC number: 801-093-8 | CAS number: 1315251-11-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Body burden: For long-term fish toxicity the NOEC is derived using the Lethal and Critical Body burden approach as described in the ECHA R.7b Guidance Appendix 7.8-3 (2017) using the structure, molecular weight, short-term toxicity to fish and the aquatic bioconcentration factor (BCF) as input data. The substance is identified as a neutral organic substance in ECOSAR 2.0 and is assumed to follow anon-polar (Type I) narcotic mode of action (acute = 1 to 10 mmol/kg, chronic = 0.1 to 1 mmol/kg; Thompson and Stewart 2003).
The Lethal Body Burden (LBB) approach for the substance is calculated first to see which mMol/kg is applicable for the CBB approach. The used equation for long-term fish toxicity is CBB mMol/kg fish = NOEC mMol/L x BCF. The CBB is estimated to between 0.1 and 1 mMol/kg fish. The LBB (LBB mMol/kg fish = LC50 mMol/L x BCF) calculation for the substance results in 1.166 mMol/kg fish (using LC50 of 0.55 mg/L, BCF of 513 L/kg and a molecular weight of 242). This LBB value shows that for the CBB approach the 0.117 mMol/kg fish can be used (instead of 0.1 or 1 mMol/kg fish). The long-term fish NOEC thus becomes 0.055 mg/L (0.117 mMol/kg = NOEC mMol/L x 513 (molecular weight 242).
Uncertainty of the predictions in LBB/CBB approach: The LBB and CBB approaches are most applicable to narcotic type of chemicals. As described above, based on the structure, the substance is a neutral organic substance with a narcotic mode of action (baseline toxicity). Thus it is not assumed to have a specific mode of action. Furthermore, even though the short--term toxicity to fish and aquatic bioaccumulation studies have been performed with different fish species, the BCF used here is normalised to 5% lipid content which should diminish any further uncertainty. In view of the reasoning above, the uncertainty of the CBB prediction is limited. The long-term fish toxicity of substance derived is considered reliable.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Dose descriptor:
- NOEC
- Effect concentration:
- 0.055 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.