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Reaction mass of Cobaltate(3-), bis[2-[[[3-[2-[1-[[(2-chlorophenyl)amino]carbonyl]-2-(oxo-κO)propyl]diazenyl-κN1]-4-(hydroxy-κO)phenyl]sulfonyl]amino]benzoato(3-)]-, sodium (1:3) and tetrasodium bis[2-[[[3-[[1-[(2-chloroanilino)carbonyl]-2-oxopropyl]azo]-4-hydroxyphenyl]sulphonyl]amino]benzoato(3-)]cobaltate(4-)
EC number: 941-792-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 28 April, 2014 to 04 September, 2014
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Radiolabelling:
- no
- Details on sampling:
- The test item solutions were prepared by adding 1 mL stock solution into a 100 mL volumetric flask and accurately filled up with the buffer solutions. Under argon atmosphere 2.0 mL of the test item solutions were given into several crimped glass vials. The vials were closed with Teflon sealed screw caps. At the sampling time 2 mL methanol + 1 % phosphoric acid were added (d = 2). The concentration did not exceed 0.01 M or the half saturation concentration. The determined effective concentrations prior to storage at 50 °C were 9.50 mg/L at pH 4, 10.1 mg/L at pH 7 and 10.2 mg/L at pH 9.
- Buffers:
- The test was carried out at three different pH values: 4.0, 7.0 and 9.0. For this purpose, buffer solutions were prepared using reagent grade chemicals and deionized water. Applicable buffer systems are described in the Appendix of EC method C.7 (92/69/EC), OECD Guideline 111.
The citrate buffer pH 4, the phosphate buffer pH 7 and the borate buffer pH 9 were prepared in a concentration of 0.05 M on the basis of the undissociated acids. The pH value of the buffer solutions used during the test were determined with a calibrated pH meter at the selected temperature with a precision of 0.01 pH units. - Details on test conditions:
- Preliminary Test:
A preliminary test was performed at 50±0.5 °C at three pH values: 4.0, 7.0 and 9.0. A sufficient number of measurements were made, in order to be able to estimate whether for each pH value and at 50 °C, the half-life time (t1/2) is less than 10 % of hydrolysis after 120 hours. These values correspond to a half-life time higher than one year under conditions more representative of those of the environment (25 °C).
Hydrolysis of unstable Substances (Tier 2):
The Main Test (Tier 2) was performed at pH 4, 7 and 9. The buffered solution of the test substance was thermostated at 20 °C and 40 °C. To test for first-order behaviour, each reaction solution was analysed in time intervals which provide at least six spaced data points normally between 10 % and 90 % hydrolysis of the substance. Individual replicate test samples (a minimum of duplicate samples contained in separate reaction vessels) were removed and the contents were analysed at each of at least six sampling times (for a minimum of twelve replicate data points). Kinetic analysis for the hydrolysis of unstable substances (Tier 2) was performed and the corresponding DT50 values was calculated. At each sampling date the pH was determined. - Duration:
- 120 h
- pH:
- 4
- Temp.:
- 50 °C
- Initial conc. measured:
- 9.5 mg/L
- Duration:
- 771 h
- pH:
- 4
- Temp.:
- 40 °C
- Initial conc. measured:
- 10.1 mg/L
- Duration:
- 771 h
- pH:
- 4
- Temp.:
- 20 °C
- Initial conc. measured:
- 10.2 mg/L
- Duration:
- 120 h
- pH:
- 7
- Temp.:
- 50 °C
- Initial conc. measured:
- 10.1 mg/L
- Duration:
- 771
- pH:
- 7
- Temp.:
- 40 °C
- Initial conc. measured:
- 10.4 mg/L
- Duration:
- 771
- pH:
- 7
- Temp.:
- 20 °C
- Initial conc. measured:
- 10.4 mg/L
- Duration:
- 120 h
- pH:
- 9
- Temp.:
- 50 °C
- Initial conc. measured:
- 10.2 mg/L
- Duration:
- 771 h
- pH:
- 9
- Temp.:
- 40 °C
- Initial conc. measured:
- 10.3 mg/L
- Duration:
- 771 h
- pH:
- 9
- Temp.:
- 20 °C
- Initial conc. measured:
- 10.4 mg/L
- Number of replicates:
- Preliminary Test:
4 at each pH-value
Hydrolysis of unstable Substances (Tier 2):
16 at pH 4 at each temperature (20 and 40 °C)
18 at pH 7 at 40 °C
16 at pH 7 at 20 °C
18 at pH 9 at 40 °C
16 at pH 9 at 20 °C - Preliminary study:
- A preliminary test was performed at 50±0.5 °C at three pH values: 4.0, 7.0 and 9.0. A sufficient number of measurements were made, in order to be able to estimate whether for each pH value and at 50 °C, the half-life time (t1/2) is less than 10 % of hydrolysis after 120 hours. These values correspond to a half-life time higher than one year under conditions more representative of those of the environment (25 °C).
- Test performance:
- The main test (Tier 2) was performed at pH 4, 7 and 9. The buffered solution of the test substance was thermostated at 20 °C and 40 °C. To test for first-order behaviour, each reaction solution was analysed in time intervals which provide at least six spaced data points normally between 10 % and 90 % hydrolysis of the substance. Individual replicate test samples (a minimum of duplicate samples contained in separate reaction vessels) were removed and the contents were analysed at each of at least six sampling times (for a minimum of twelve replicate data points). Kinetic analysis for the hydrolysis of unstable substances (Tier 2) was performed and the corresponding DT50 values was calculated. At each sampling date the pH was determined.
- Transformation products:
- not measured
- % Recovery:
- 89.9
- pH:
- 4
- Temp.:
- 50 °C
- Duration:
- 120 h
- % Recovery:
- 95.5
- pH:
- 4
- Temp.:
- 20 °C
- Duration:
- 771 h
- % Recovery:
- 89.3
- pH:
- 4
- Temp.:
- 40 °C
- Duration:
- 771 h
- % Recovery:
- 89.5
- pH:
- 7
- Temp.:
- 50 °C
- Duration:
- 120 h
- % Recovery:
- 86.7
- pH:
- 7
- Temp.:
- 20 °C
- Duration:
- 771 h
- % Recovery:
- 85.1
- pH:
- 7
- Temp.:
- 40 °C
- Duration:
- 771 h
- % Recovery:
- 49.4
- pH:
- 9
- Temp.:
- 50 °C
- Duration:
- 120 h
- % Recovery:
- 72.5
- pH:
- 9
- Temp.:
- 20 °C
- Duration:
- 771 h
- % Recovery:
- 45
- pH:
- 9
- Temp.:
- 40 °C
- Duration:
- 771 h
- pH:
- 4
- Temp.:
- 40 °C
- DT50:
- 6 759 h
- Type:
- (pseudo-)first order (= half-life)
- pH:
- 4
- Temp.:
- 20 °C
- DT50:
- 12 904 h
- Type:
- (pseudo-)first order (= half-life)
- pH:
- 7
- Temp.:
- 40 °C
- DT50:
- 5 495 h
- Type:
- (pseudo-)first order (= half-life)
- pH:
- 7
- Temp.:
- 20 °C
- DT50:
- 3 697 h
- Type:
- (pseudo-)first order (= half-life)
- pH:
- 9
- Temp.:
- 40 °C
- DT50:
- 444 h
- Type:
- (pseudo-)first order (= half-life)
- pH:
- 9
- Temp.:
- 20 °C
- DT50:
- 1 603 h
- Type:
- (pseudo-)first order (= half-life)
- Details on results:
- The degradation of FAT 92368/Y was more than 10 % at pH 4, 7 and 9 at 50 °C over a period of 120 hours. A Tier 2 test at 40 °C and 20 °C was performed at pH 4, 7 and 9.
Table: Degradation endpoint for hydrolysis of FAT 92368/Y
Test system Kinetic model DT50 [h]
pH 4, 40 °C SFO 6759
pH 4, 20 °C SFO 12904
pH 7, 40 °C SFO 5495
pH 7, 20 °C SFO 3697
pH 9, 40 °C SFO 444
pH 9, 20 °C SFO 1603 - Validity criteria fulfilled:
- yes
- Conclusions:
- The hydrolytic half-life at pH 7 and 20 °C was 3697 hours.
- Executive summary:
The abiotic degradation of FAT 92368/Y as a function of pH in aqueous solution was determined according to OECD guideline 111 and EC method C.7 (440/2008). The degradation of FAT 92368/Y was more than 10 % at pH 4, 7 and 9 at 50 °C over a period of 120 hours. A Tier 2 test at 40 °C and 20 °C was performed at pH 4, 7 and 9. The observed degradation rates found were summarised in the following table.
Test system
Kinetic model
DT50
[h]pH 4, 40 °C
SFO
6759
pH 4, 20 °C
SFO
12904
pH 7, 40 °C
SFO
5495
pH 7, 20 °C
SFO
3697
pH 9, 40 °C
SFO
444
pH 9, 20 °C
SFO
1603
Reference
Table: Time course of FAT 92368/Y concentration at pH 4 at 50 °C
Time | Determined content of FAT 92368/Y in sample | Actual concentration | |
[h] | [mg/L] | in % of initial conc. | |
0 | 9.50 | 100 | |
120 | 8.54 | 89.9 | |
10.1 % of the test item were hydrolysed at pH 4 within 120 hours at 50 °C. A Main Test (Tier 2) was enclosed to determine the kinetic time course.
Table: Time course of FAT 92368/Y concentration at pH 7 at 50 °C
Time | Determined content of FAT 92368/Y in sample | Actual concentration | |
[h] | [mg/L] | in % of initial conc. | |
0 | 10.1 | 100 | |
120 | 9.04 | 89.5 | |
10.5 % of the test item were hydrolysed at pH 7 within 120 hours at 50 °C. A Main Test (Tier 2) was enclosed to determine the kinetic time course.
Table: Time course of FAT 92368/Y concentration at pH 9 at 50 °C
Time | Determined content of FAT 92368/Y in sample | Actual concentration | |
[h] | [mg/L] | in % of initial conc. | |
0 | 10.2 | 100 | |
120 | 5.04 | 49.4 | |
50.6 % of the test item were hydrolysed at pH 9 within 120 hours at 50 °C. A Main Test (Tier 2) was enclosed to determine the kinetic time course.
Table: Time course of FAT 92368/Y concentration at pH 4 at 40 °C
Time | Conc. in 2 independent samples | Mean Conc. from 2 independent samples | Conc. in % of initial concentration |
|
[h] | [mg/L] | [mg/L] | [%] |
|
0 | 9.976 | 10.1 | 100 | 0.0000 |
10.14 | ||||
23 | 9.490 | 9.45 | 93.6 | -0.0287 |
9.405 | ||||
95 | 9.456 | 9.40 | 93.1 | -0.0311 |
9.345 | ||||
195 | 9.244 | 9.29 | 92.0 | -0.0362 |
9.330 | ||||
431 | 8.992 | 8.98 | 88.9 | -0.0511 |
8.963 | ||||
600 | 9.145 | 9.10 | 90.1 | -0.0453 |
9.064 | ||||
695 | 9.101 | 9.11 | 90.2 | -0.0448 |
9.117 | ||||
771 | 8.976 | 9.02 | 89.3 | -0.0491 |
9.071 |
The test was stopped after 30 days. 89.3 % of the initial concentration was found after 30 days at pH 4 at 40 °C.
Table: Time course of FAT 92368/Y concentration at pH 4 at 20 °C
Time | Conc. in 2 independent samples | Mean Conc. from 2 independent samples | Conc. in % of initial concentration |
|
[h] | [mg/L] | [mg/L] | [%] |
|
0 | 10.19 | 10.2 | 100 | 0.00000 |
10.16 | ||||
23 | 10.06 | 10.1 | 99.0 | -0.00428 |
10.12 | ||||
95 | 10.07 | 10.0 | 98.0 | -0.00860 |
10.02 | ||||
195 | 9.911 | 9.91 | 97.2 | -0.0125 |
9.914 | ||||
431 | 9.774 | 9.77 | 95.8 | -0.0187 |
9.767 | ||||
600 | 9.805 | 9.76 | 95.7 | -0.0192 |
9.708 | ||||
695 | 9.775 | 9.76 | 95.7 | -0.0192 |
9.743 | ||||
771 | 9.731 | 9.74 | 95.5 | -0.0200 |
9.757 |
The test was stopped after 30 days. 95.5 % of the initial concentration was found after 30 days at pH 4 at 20 °C.
Table: Time course of FAT 92368/Y concentration at pH 7 at 40 °C
Time | Conc. in 2 independent samples | Mean Conc. from 2 independent samples | Conc. in % of initial concentration |
|
[h] | [mg/L] | [mg/L] | [%] |
|
0 | 10.32 | 10.4 | 100 | 0.0000 |
10.38 | ||||
23 | 9.269 | 9.27 | 89.1 | -0.0501 |
9.265 | ||||
95 | 9.011 | 9.01 | 86.6 | -0.0625 |
9.017 | ||||
117 | 9.025 | 9.03 | 86.8 | -0.0615 |
9.037 | ||||
167 | 9.022 | 9.02 | 86.7 | -0.0620 |
9.018 | ||||
195 | 8.911 | 8.91 | 85.7 | -0.0670 |
8.916 | ||||
431 | 8.824 | 8.83 | 84.9 | -0.0711 |
8.841 | ||||
600 | 8.821 | 8.84 | 85.0 | -0.0706 |
8.866 | ||||
771 | 8.847 | 8.85 | 85.1 | -0.0701 |
8.856 |
The test was stopped after 30 days. 85.1 % of the initial concentration was found after 30 days at pH 7 at 40 °C.
Table: Time course of FAT 92368/Y concentration at pH 7 at 20 °C
Time | Conc. in 2 independent samples | Mean Conc. from 2 independent samples | Conc. in % of initial concentration |
|
[h] | [mg/L] | [mg/L] | [%] |
|
0 | 10.39 | 10.4 | 100 | 0.00000 |
10.44 | ||||
23 | 10.24 | 10.3 | 99.0 | -0.00420 |
10.28 | ||||
95 | 10.05 | 10.0 | 96.2 | -0.0170 |
10.02 | ||||
195 | 9.648 | 9.68 | 93.1 | -0.0312 |
9.702 | ||||
431 | 9.283 | 9.27 | 89.1 | -0.0500 |
9.261 | ||||
600 | 9.134 | 9.13 | 87.8 | -0.0566 |
9.122 | ||||
695 | 8.985 | 9.04 | 86.9 | -0.0609 |
9.090 | ||||
771 | 8.997 | 9.02 | 86.7 | -0.0618 |
9.051 |
The test was stopped after 30 days. 86.7 % of the initial concentration was found after 30 days at pH 7 at 20 °C.
Table: Time course of FAT 92368/Y concentration at pH 9 at 40 °C
Time | Conc. in 2 independent samples | Mean Conc. from 2 independent samples | Conc. in % of initial concentration |
|
[h] | [mg/L] | [mg/L] | [%] |
|
0 | 10.30 | 10.3 | 100 | 0.0000 |
10.37 | ||||
23 | 8.303 | 8.29 | 80.5 | -0.0942 |
8.285 | ||||
95 | 5.912 | 5.91 | 57.4 | -0.241 |
5.915 | ||||
117 | 5.770 | 5.78 | 56.1 | -0.251 |
5.780 | ||||
167 | 5.413 | 5.42 | 52.6 | -0.279 |
5.433 | ||||
195 | 5.155 | 5.17 | 50.2 | -0.299 |
5.180 | ||||
431 | 4.837 | 4.78 | 46.4 | -0.333 |
4.730 | ||||
600 | 4.704 | 4.69 | 45.5 | -0.342 |
4.670 | ||||
771 | 4.675 | 4.64 | 45.0 | -0.347 |
4.613 |
The test was stopped after 30 days. 45.0 % of the initial concentration was found after 30 days at pH 9 at 40 °C.
Table: Time course of FAT 92368/Y concentration at pH 9 at 20 °C
Time | Conc. in 2 independent samples | Mean Conc. from 2 independent samples | Conc. in % of initial concentration |
|
[h] | [mg/L] | [mg/L] | [%] |
|
0 | 10.32 | 10.4 | 100 | 0.00000 |
10.43 | ||||
23 | 10.28 | 10.3 | 99.0 | -0.00420 |
10.28 | ||||
95 | 9.92 | 9.91 | 95.3 | -0.0210 |
9.90 | ||||
195 | 9.376 | 9.37 | 90.1 | -0.0453 |
9.362 | ||||
431 | 8.226 | 8.29 | 79.7 | -0.0985 |
8.361 | ||||
600 | 7.942 | 7.93 | 76.3 | -0.118 |
7.912 | ||||
695 | 7.745 | 7.72 | 74.2 | -0.129 |
7.703 | ||||
771 | 7.562 | 7.54 | 72.5 | -0.140 |
7.521 |
The test was stopped after 30 days. 72.5 % of the initial concentration was found after 30 days at pH 9 at 20 °C.
Table: Degradation endpoint for hydrolysis of FAT 92368/Y
Test system | Kinetic model | slope a | Y-axis intercept b | DT50 |
pH 4, 40 °C | SFO | -4.14.10-05 | -2.12.10-02 | 6759 |
pH 4, 20 °C | SFO | -2.30.10-05 | -4.74.10-03 | 12904 |
pH 7, 40 °C | SFO | -4.66.10-05 | -4.48.10-02 | 5495 |
pH 7, 20 °C | SFO | -7.95.10-05 | -7.30.10-03 | 3697 |
pH 9, 40 °C | SFO | -3.27.10-04 | -1.56.10-01 | 444 |
pH 9, 20 °C | SFO | -1.85.10-04 | -4.53.10-03 | 1603 |
Description of key information
The hydrolytic half-life at pH 7 and 20 °C was 3697 hours.
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 3 697 h
- at the temperature of:
- 20 °C
Additional information
The abiotic degradation of FAT 92368/Y as a function of pH in aqueous solution was determined according to OECD guideline 111 and EC method C.7 (440/2008). The degradation of FAT 92368/Y was more than 10 % at pH 4, 7 and 9 at 50 °C over a period of 120 hours. A Tier 2 test at 40 °C and 20 °C was performed at pH 4, 7 and 9. The observed degradation rates found were summarised in the following table.
Test system | Kinetic model | DT50 |
pH 4, 40 °C | SFO | 6759 |
pH 4, 20 °C | SFO | 12904 |
pH 7, 40 °C | SFO | 5495 |
pH 7, 20 °C | SFO | 3697 |
pH 9, 40 °C | SFO | 444 |
pH 9, 20 °C | SFO | 1603 |
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Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.