Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 701-373-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Qualifier:
- according to guideline
- Guideline:
- other: REACH Guidance Document “Guidance on information requirements and chemical safety assessment Chapter R.7a: Endpoint specific guidance”
- Version / remarks:
- 2017
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- 2014
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 1995
- Deviations:
- no
- GLP compliance:
- not specified
- Type of method:
- flask method
- Key result
- Water solubility:
- >= 9.18 - <= 43.02 mg/L
- Conc. based on:
- other: Nominal concentration of test substance
- Incubation duration:
- 1 h
- Temp.:
- 20 °C
- pH:
- >= 5.8 - <= 5.99
- Remarks on result:
- other: No exact value for the solubility of the test substance in water can be stated.
- Remarks:
- corresponding to 9.2 - 4.3 % of the test substance relating to the nominal concentration of the test substance.
- Details on results:
- As the solubility was dependent on the nominal concentration, no exact value for the solubility of the test substance in water can be stated. The solubility range for the tested nominal concentration 100-1004 mg/L was 9.18 - 43.02 mg/L at 20.0°C, corresponding to 9.2 – 4.3 % of the test substance relating to the nominal concentration of the test substance. No observations arousing doubts concerning the accuracy of the results and the validity of the study were made.
- Conclusions:
- Under the study conditions, no exact value for the solubility of the test substance in water can be stated.
- Executive summary:
The solubility of the test substance without diluting monomer in water was determined according to EU method A.6 and OECD TG 105 by measurement of DOC concentration in the filtrated test solutions using TOC analyser. Prior to this, the carbon content of the test substance was determined by elemental analysis, resulting in a value of 67.34 %. This value was used in the calculation of the test substance concentration from the measured DOC concentration.
In the preliminary test, the measured DOC concentration was 1.43 mg/L and 25.92 mg/L in the flasks with the nominal load 10.2 mg/L and 1001 mg/L, respectively. As dependency of the water solubility on the amount of the test substance added was observed, different loading rates were used in the main test. According to the guideline the flask method was used for the determination of the solubility of the test substance in water.
In the main test, six different loading rates of the test substance were chosen to study the effect of the loading rate on the measured water solubility: 100, 302, 503, 600, 802 and 1004 mg/L. Three flasks (1A-1C) with the same loading rate (500 mg/L, nominal) were used during equilibration. Due to an upward tendency of the test substance concentration, the test was prolonged and the flasks 1A-1C were measured on days 4, 8 and 9. Due to a difference of less than 15 % in the concentrations on days 8 and 9 and no upward tendency in the last three values, the test was finished. All samples were kept at 20.0 ± 0.5°C for 1 hour before filtration.
The final measurement was performed on day 10 as determination from flasks 2-6. All double filtrated test solutions showed no Tyndall effect (i.e. a laser beam was not scattered when transmitted through the liquid).
As the solubility was dependent on the nominal concentration, no exact value for the solubility of the test substance in water can be stated. The solubility range for the tested nominal concentration 100-1004 mg/L was 9.18-43.02 mg/L at 20.0°C, corresponding to 9.2-4.3 % of the test substance relating to the nominal concentration of the test substance (Affolter, 2020).
Reference
Measurements during Equilibration:
All data which was acquired during equilibration time (flask 1A-C, days 1 – 4, 8 – 9) are presented in the following table:
Day | Temperature [°C] | pH* | Concentration DOC [mg/L] | Conc. Test Substance [mg/L] | Difference [%] |
1 | 20.0 | 6 | 7.70 | 11.43 |
|
2 | 20.0 | 6 | 11.35 | 16.85 | +47.4 |
3 | 20.0 | 6 | 11.89 | 17.66 | +4.8 |
4 | 20.0 | 6 | 16.06 | 23.85 | +35.1 |
8 | 20.0 | 6 | 15.05 | 22.35 | -6.3 |
9 | 20.0 | 6 | 15.51 | 23.03 | +3.1 |
*measurement via pH paper
The carbon content of the test substance 67.34 % was used in the calculation of the test substance concentration from the measured DOC concentration according to the following equation:
cTest substance [mg/L] = cDOC [mg/L] ∗ 100%/67.34%
The measured value in the blank solution was < 0.5 mg/L TOC. After the analysis of the sample of day 9, the plateau was considered as reached.
The measured concentrations in the flasks 2 – 6 are presented in the following table:
Plateau:
Flask # | Temperature [°C] | pH* | Concentration DOC [mg/L] | Conc. Test substance [mg/L] |
2 | 20.0 | 5.89 | 6.18 | 9.18 |
3 | 20.0 | 5.99 | 15.12 | 22.45 |
4 | 20.0 | 5.80 | 22.88 | 33.98 |
5 | 20.0 | 5.97 | 24.44 | 36.29 |
6 | 20.0 | 5.94 | 28.97 | 43.02 |
*measured via calibrated pH meter
The measurements from the flasks 2 – 6 were included in the calculation of the solubility of the test substance in water. The flasks 1A – 1C were used during the equilibration time only.
Measurements used for Calculation of Solubility:
Flask # | Measured Conc. Test Substance [mg/L] | Nominal Conc. Test Substance [mg/L] | Dissolved Part [%] |
2 | 9.18 | 100 | 9.2 |
3 | 22.45 | 302 | 7.4 |
4 | 33.98 | 600 | 5.7 |
5 | 36.29 | 802 | 4.5 |
6 | 43.02 | 1004 | 4.3 |
Description of key information
The water solubility was determined according to OECD Guideline 105 and EU Method A.6 (Affolter, 2020).
Key value for chemical safety assessment
- Water solubility:
- 43.02 mg/L
- at the temperature of:
- 20 °C
Additional information
As the solubility was dependent on the nominal concentration, no exact value for the solubility of the test substance in water can be stated. The solubility range for nominal concentration of 100-1004 mg/L was 9.18-43.02 mg/L at 20.0°C, corresponding to 9.2-4.3% of the nominal concentration of the test substance.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.