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EC number: 211-059-9 | CAS number: 628-89-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The chemical 2-(2-chloroethoxy)ethanol was found to be non toxic by any of the route.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Data is from SAX and RTECS
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Control animals:
- not specified
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 6 300 other: mg/kg
- Based on:
- test mat.
- Remarks on result:
- other: Details of toxic effects not reported other than lethal dose value
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- This value suggest that the chemical 2-(2-chloroethoxy)ethanol does not exhibit acute toxicity through the oral route
- Executive summary:
Acute oral toxicity value of 2-(2-chloroethoxy)ethanol in rat was found to be LD50 :6300 mg/kg. This value suggests that the chemical 2-(2-chloroethoxy)ethanol does not exhibit acute toxicity through the oral route for classification as for classification the lethal dose should be less than 2000 mg/kg.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 6 300 mg/kg bw
- Quality of whole database:
- K2 data from relaible handbook SAX
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
- Qualifier:
- according to guideline
- Guideline:
- other: estimated data
- Principles of method if other than guideline:
- Prediction is done using QSAR Toolbox version 2.3
- GLP compliance:
- no
- Test type:
- other: Acute Rodent Inhalation Toxicity Test
- Species:
- rat
- Strain:
- Long-Evans
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Duration of exposure:
- 8 h
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- 133.4 other: mg/l
- Based on:
- test mat.
- Exp. duration:
- 8 h
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The 8h acute inhalation median lethal concentration (LC50) of 2-(2-chloroethoxy)ethanol in rat was estimated to be 133.4001 mg/L. This value indicates that 2-(2-chloroethoxy)ethanol does not exhibits acute toxicity by the inhalative route
- Executive summary:
The 8h acute inhalation median lethal concentration (LC50) of 2-(2-chloroethoxy)ethanol in rat was estimated to be 133.4001 mg/L . This value indicates that 2-(2-chloroethoxy)ethanol does not exhibits acute toxicity by the inhalative route. In order to classify the substance in inhalation category the lethal dose should be in the range of less than 20 mg/L in vapour condition.
Reference
The prediction was based on dataset comprised from the following descriptors: LC50
Estimation method: Taking average value from the 5 nearest neighbours
Domain logical expression:Result: In Domain
(("a" and "b" ) and ("c" and "d" ) )
Domain logical expression index: "a"
Similarity boundary:Target: C(Cl)COCCO
Threshold=50%,
Dice(Atom pairs)
Domain logical expression index: "b"
Similarity boundary:Target: C(Cl)COCCO
Threshold=60%,
Dice(Atom pairs)
Domain logical expression index: "c"
Parametric boundary:The target chemical should have a value of log Kow which is >= -0.529
Domain logical expression index: "d"
Parametric boundary:The target chemical should have a value of log Kow which is <= 0.516
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LC50
- Value:
- 133.4 mg/m³ air
- Quality of whole database:
- K2 data from QSAR model considered reliable by OECD
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Data is from SAX
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 3 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: other details not available
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Acute dermal toxicity (LD50) of 2-(2-chloroethoxy)ethanol in guinea pig was found to be 3000 mg/Kg. This value indicates that 2-(2-chloroethoxy)ethanol is not toxic to skin of guinea pig
- Executive summary:
Acute dermal toxicity (LD50) of 2-(2-chloroethoxy)ethanol in guinea pig was found to be 3000 mg/Kg. This value suggests that 2-(2-chloroethoxy) ethanol is not toxic to skin of guinea pig. In order to classify the substance in dermal category the lethal dose should be in the range of less than 2000 mg/kg in normal condition.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 3 000 mg/kg bw
- Quality of whole database:
- K2 data from relaible handbook SAX
Additional information
Acute Toxicity :
Acute toxicity : Oral
Acute oral toxicity value of 2-(2-chloroethoxy)ethanol in rat was found to be LD50 :6300 mg/kg. This value suggest that the chemical 2-(2-chloroethoxy)ethanol does not exhibit acute toxicity through the oral route
Acute toxicity : Inhalation
The 8h acute inhalation median lethal concentration (LC50) of 2-(2-chloroethoxy)ethanol in rat was estimated to be 133.4001 mg/L. This value indicates that 2-(2-chloroethoxy)ethanol does not exhibits acute toxicity by the inhalative route
No of studies reviewed for Acute toxicity: inhalation from reliable sources having Klimish rating 2
The summary if the results are presented below
Sr. No |
Endpoint name |
Value |
Units |
Species |
1 |
LC50 | 133.4001 | mg/l | Rat |
2 | LC50 | 70.87939 | mg/l | Mouse |
Based on the above endpoint values it can be concluded that the substance is classified as non toxic based on classification criteria .
Acute toxicity : Dermal
Acute dermal toxicity (LD50) of 2-(2-chloroethoxy)ethanol in guinea pig was found to be 3000 mg/Kg. This value indicates that 2-(2-chloroethoxy)ethanol is not toxic to skin of guinea pig
Justification for selection of acute toxicity – oral endpoint
Acute oral toxicity value of 2-(2-chloroethoxy)ethanol in rat was found to be LD50 :6300 mg/kg. This value suggests that the chemical 2-(2-chloroethoxy)ethanol does not exhibit acute toxicity through the oral route for classification as for classification the lethal dose should be less than 2000 mg/kg.
Justification for selection of acute toxicity – inhalation endpoint
The 8h acute inhalation median lethal concentration (LC50) of 2-(2-chloroethoxy)ethanol in rat was estimated to be 133.4001 mg/L . This value indicates that 2-(2-chloroethoxy)ethanol does not exhibits acute toxicity by the inhalative route. In order to classify the substance in inhalation category the lethal dose should be in the range of less than 20 mg/L in vapour condition.
Justification for selection of acute toxicity – dermal endpoint
Acute dermal toxicity (LD50) of 2-(2-chloroethoxy)ethanol in guinea pig was found to be 3000 mg/Kg. This value suggests that 2-(2-chloroethoxy) ethanol is not toxic to skin of guinea pig. In order to classify the substance in dermal category the lethal dose should be in the range of less than 2000 mg/kg in normal condition.
Justification for classification or non-classification
The available studies indicate that 2-(2-chloroethoxy)ethanol is not classified as a acute toxicity by any of the route (oral, dermal and inhalation), according to the C & L regulation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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