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EC number: 617-143-5 | CAS number: 80675-49-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Based on its physicochemical properties and study observations systemic systemic uptake of Butanamide 2-[2-(2-methoxy-5-nitrophenyl)diazenyl]-N-(2-methoxyphenyl)-3-oxo- is unlikely but cannot be excluded. The insolubility in water and poor solubility in octanol do not favor passage of biological membranes. The logPOW and the molecular weight are however in a range for which systemic uptake is assumed. The substance contains functional groups known to be susceptible to enzyme-catalysed transformations. Both conjugating reactions as well as hydrolysis are in theory possible. Hydrolysis would reduce the conjugated sytem and result in non-coloured substances.
The fact that the substance was found to be non-hazardous up to the limit dose upon subacute oral studies is strongly in favour of absence of systemic uptake or hydrolysis. Theoretical hydrolysis products would have an aromatic amine core and therefore any uptake and hydrolysis would have been resulted in adverse effects. Conjugated Phase II-metabolites would keep the yellow colour and are expected to be non-toxic.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
Toxicokinetic analysis of Butanamide 2-[2-(2-methoxy-5-nitrophenyl)diazenyl]-N-(2-methoxyphenyl)-3-oxo-
The test substance is a solid yellow powder at room temperature with a molecular weight (MW) of 386.36 g/mol. It is almost insoluble in water (19.0 µg/L at 20 °C, pH 6) as well as in organic solvent (n-octanol, 4.05 mg/L) and has a log Pow of 2.3 (at 23 °C, pH 5). The molecule is a conjugated system of rigid shape.
Absorption
A screening study for reproductive/developmental toxicity according to OECD 421 reported a transient discoloration of the fur as well as urine and faeces (BASF SE, 2011). As the substance was applied via the diet, coloration of the fur is related to external contamination from the colorant in the feed. Yellow discoloration of feces indicates passage through the intestine without destruction of the chromophore. Whether yellow coloration of urine is indicator of uptake is questionable since urine is naturally yellow and the intensity of the color is related to its concentration.
According to the solid state of Butanamide 2-[2-(2-methoxy-5-nitrophenyl)diazenyl]-N-(2-methoxyphenyl)-3-oxo-, exposure to the test substance as vapor is very limited if handled at room temperature (vapour pressure < 1.0E -6 hPa). Considering the MMD of the test substance (66.0 µm) it is very unlikely that inhaled particles reach the tracheal, bronchial or alveolar region of the respiratory tract. If inhaled, the low water soluble test substance will not dissolve in the mucus of the respiratory tract. However, particles inhaled or deposited in the oropharynx could be coughed out and swallowed into the GI tract, possibly leading to intestinal absorption. These assumptions are based on the physico-chemical properties of the test substance, since no repeated-dose data of inhalation studies were available.
Particles of the test substance will have to dissolve into the surface moisture of the skin before absorption. Considering the non-hydrophilic character and the low solubility, the test substance will dissolve hardly in the surface moisture.
Dermal uptake of substances < 100 g/mol is favored. The MW of the test substance of 386.36 g/mol hinders dermal absorption. According to the solubility (19.0 µg/L) a minimal dermal uptake can be anticipated. Furthermore, the log Pow of 2.3 and the poor solubility in organic solvents (4.05 mg/L in n-octanol) will limit penetration into the stratum corneum and hence dermal absorption. It can be assumed that dermal absorption of the test substance is limited.
Distribution
In the oral studies, no discoloration of organs and absence of target organ toxicity was observed.
Metabolism
No data on metabolism is available. The structure contains a number of functional groups that are in theory known to be susceptible to enzymatic transformations. These include both hydrolytic and non-hydrolyic type transformations.
Excretion
The available data shows that at least a major fraction is eliminated via the feces.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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